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- PTC124 is an orally administered small molecule that targets a type of disease-causing genetic error known as a nonsense mutation, or premature stop codon. PTC124是一種口服式小分子化合物，它的標的是針對一些因為”無(wú)義”基因突變的疾病。
- The precore stop codon mutation was found in 7 AsCs and 10 CAH cases. AsC與CAH組中，前C終28變異分別為7例和10例；
- An "agg" codon between 1039-1041bp in PLF gene was replaced with a "taa" stop codon through primers design and PCR. 豬乳鐵蛋白基因1039-1041bp處為agg密碼子，在設計引物時(shí)突變?yōu)閠aa終止密碼子。
- Three other tumors contained heteroplasmic COI mutations, one of which created a stop codon. 接著(zhù)，他們對來(lái)自260個(gè)前列腺癌組織樣品或血細胞的COI基因進(jìn)行了測序。
- Stop codon was knocked down from porcine IFN gene when the downstream primer was designed. 此信號肽能引導目的蛋白離開(kāi)細胞，分泌于培養基中，方便蛋白質(zhì)提取與純化。
- This mutation predicts the substitute of glutamic acid at codon 189 by the stop codon (Glu189X or E189X). 該突變導致第189位編碼谷氨酸的密碼子被終止密碼代替（E189X）。
- The total number of nucleotides between a stop codon of rbcL gene and a HindIII site in cemA gene were 2 808 and 2 810 bp in Ae. 從rbcL基因的終止密碼子到cemA基因內的HindIII位點(diǎn);Ae.
- Using the home-made Perl programs, we extracted the concerned bases upstream and downstream of both the initiator codon and the stop codon for analysis. 通過(guò)自編的系列Perl程序，從智人RefSeq數據庫中分別抽取mRNA序列起始密碼子、終止密碼子上、下游一定數目堿基進(jìn)行分析，得出以下主要結論：
- DNA sequencing revealed that the IPNS gene of S. cattleya consists of 963 bp encoding a protein of 321 amino acids with ATG as start codon, TGA as stop codon. 經(jīng)基因序列分析表明牲畜鏈霉菌中IPNS基因;由963bp組成;起始密碼子為ATG;終止密碼子為T(mén)GA;共編碼321個(gè)氨基酸;所克隆的牲畜鏈霉菌IPNS基因編碼蛋白與已知的S.
- A protein called a release factor binds directly to the stop codon, causing the addition of a water molecule instead of an amino acid to the polypeptide chain. 一種叫做釋放因子的蛋白質(zhì)直接結合在終止密碼子上，導致一個(gè)水分子而不是氨基酸被加在肽鏈末端。
- The underlined nucleotides are the first upstream in-frame stop codon and the two putatie polyadenylation signals, respectiely.The asterisk indicates the stop codon. 加下劃線(xiàn)的核苷酸分別是這個(gè)讀碼框中上游的第一個(gè)終止密碼和兩個(gè)已經(jīng)認定的多核苷酸序列.;星號標記的就是終止密碼
- However hybridomas derived from the MOPC-21 myeloma ancestor contains two kinds of kappa chain transcripts, namely the correct (functional) and aberrant one, which causes the VJ rearrangement out of the normal reading frame, and results in a stop codon. 目前多數骨髓瘤細胞系來(lái)源于MOPC-21細胞，而且含有兩種k輕鏈轉錄子，即正常(功能性)和異常輕鏈轉錄子。
- In vitro synthesized protein assay(IVSP), which selectively detected any mutation generating stop codon, was used for rapid detection of APC gene mutation in 115 cases of non FAP colorectal tumors. 為了快速檢出APC基因突變，應用選擇性檢測產(chǎn)生終止密碼突變的體外蛋白合成試驗（IVSP），對115例Non－FAP大腸腫瘤標本進(jìn)行了研究。
- There was only one mutant , the NO. 880 base to down-side the translation stop codon (TAA).But the mutant was dispeared when conpare it with the sequence of Streptococcus mutans reported in Genebank. 本實(shí)驗將反向PCR方法與核酸內切酶設計相結合誘導變形鏈球菌乳酸脫氫酶基因缺失突變，實(shí)驗證實(shí)該方法只需設計一對反向PCR引物，進(jìn)行一輪PCR反應，一次酶切連接反應，方法簡(jiǎn)便快捷。
- This method returns true if it decides that the DrawImage method should prematurely stop execution. 如果此方法決定DrawImage方法應過(guò)早停止執行,則此方法返回true。
- The baby was five weeks premature. 這個(gè)孩子是提早五周生下來(lái)的。
- He ventured a premature opinion at the meeting. 他在會(huì )上大膽發(fā)表了一個(gè)不成熟的意見(jiàn)。
- She was a bit too premature in giving up this job. 她放棄這份工作似嫌太草率。
- Premature babies are kept alive in incubators. 早產(chǎn)嬰兒放在保溫箱里保育。
- This disease produces premature aging of the brain. 這種疾病使大腦過(guò)早衰老。
