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- The NBS1 is a component of the MRE11/RAD50/NBS1 complex (MRN) and plays a critical role in the DNA double strand break (DSB) repair and the maintenance of chromosomal integrity. NBS1作為MRE11/RAD50/NBS1復合物的組分之一,是細胞應答DNA損傷的一個(gè)關(guān)鍵蛋白質(zhì),在DNA雙鏈斷裂修復和維持基因組穩定中發(fā)揮重要的作用。
- Radiosensitization effect of 3-aminobenzamide( 3-AB), a specific inhibitor of ADP-ribose transferase( ADPRT), on cell colony formation and DNA double strand break (DSB), repair of human tumor cells was studied. 目的：從細胞的克隆形成能力和細胞DNA雙鏈斷裂及修復幾方面探討了ADP－核糖基轉移酶（ADPRT）的特異性抑制劑3－氨基苯甲酰胺（3－AB）對人卵巢癌細胞株HOC8的放射增敏效應。 結果表明，3－AB能降低受照細胞的克隆形成能力；
- Using plasmid pGEM-3Zf(-) and M13mpl8 RF DNA, this thesis studied the DNA damage (DNA single strand break (SSB) and double strand break (DSB)), and gene mutation spectra induced by 30keV N+, C+ ions. 本文以質(zhì)粒、噬菌體為實(shí)驗材料，主要研究30keV的N~+、C~+引起的DNA分子損傷(單雙鏈斷裂)和它誘發(fā)基因突變的特點(diǎn)和規律。
- Objective To construct DNA double strand break(DSB) repair protein hKu70 deficient cell strain and to observe its biological characters for studying the functions of hKu 70 gene and the effects of occupational harmfulness factors on DSB repair. 目的 建立并鑒定DNA雙鏈斷裂 (DSB)修復蛋白hKu70缺陷細胞株 ,并觀(guān)察該缺陷細胞的某些生物學(xué)效應 ,用于hKu70基因功能及職業(yè)有害因素對DNA雙鏈斷裂修復影響的研究。
- Pulsed field gel electrophoresis has been applied to compare the sensitivity of B16 cells and their DNA molecules in the induction of DNA double strand breaks (DSB) by 50 MeV/u 12 C 6+ beam. 用倒轉脈沖場(chǎng)凝膠電泳 (PIGE)比較研究了 50 Me V/u1 2 C6 +輻照小鼠 B1 6黑色素瘤細胞及其脫蛋白 DNA分子 ,從而誘導 DNA雙鏈斷裂 (DSB)的輻射敏感性。
- In this experiment, DNA double strand breaks induced by heavy ions in the early period were investigated with atomic force microscopy (AFM). 本實(shí)驗旨在用原子力顯微鏡(AFM)研究重離子輻射后早期的DNA雙鏈斷裂。
- HR can repair the DNA double strand breaks (DSBs) which is the most severe damage of DNA. It is not known whether Hp induce the occurrence of GCa by inhibiting the functions of BER genes and HR genes? HR是真核細胞修復DNA雙鏈斷裂(DNA double strand breaks, DSBs)的一個(gè)重要途徑, HR相關(guān)基因的缺陷可引起DSBs修復減少,腫瘤發(fā)生率顯著(zhù)增加。
- DNA double strand break and repair of human tumor cells irradiated by high LET heavy ions 高LET重離子照射人腫瘤細胞的DNA雙鏈斷裂及修復研究
- deoxyribonucleic acid double strands break 雙鏈脫氧核糖核酸斷裂
- THE EFFICIENCY AND FIDELITY OF REJOINING OF THE DNA DOUBLE STRAND BREAK IN THE IMMUNOCYTES OF TONSILS OF IRRADIATED MICE 小鼠扁桃體免疫細胞受照射后DNA雙鏈斷裂損傷修復的忠實(shí)性
- It has linear double strand DNA,icosahedral-capsid and envelope. 其核酸結構為線(xiàn)狀雙股DNA,衣殼為二十面體對稱(chēng),有囊膜。
- Furthermore, measuring irradiationinduced DNA strand breaks with this modified method, G(SSB) and G(DSB) consisted with other researches were obtained. 以此改進(jìn)方法檢測電離輻射誘導的DNA單、雙鏈斷裂，可得到與其它研究結果相一致的G(SSB)和G(DSB)值。
- Relationship between the Constitutes of DNA Double Strand Breaks and Scavenging Capacity DNA雙鏈斷裂的組成與自由基清除效能的關(guān)系
- Measurement of DNA Double Strand Breaks in Mammalian Cells After Ionizing Radiation by Pulsed Field Gel Electrophoresis 用脈沖電場(chǎng)凝膠電泳檢測電離輻射所致哺乳動(dòng)物細胞DNA雙鏈斷裂
- Keywords DNA double strand breaks;non-homologous end joining;DNA-dependent protein kinase;telomere;viral integration; DNA雙鏈斷裂;非同源末端連接;DNA依賴(lài)蛋白激酶;端粒;病毒整合;
- Low-energy nitrogen ion irradiation can efficiently induce single-, double- strand breaks with the ratio of 6 to 1(DSB/SSB), indicating that DSB may be the main production induced by low-energy heavy ions. 能量為30keV N~+照射干燥的質(zhì)粒DNA能有效的產(chǎn)生單鏈斷裂(SSB)和雙鏈斷裂(DSB)，有趣的是兩種斷裂的產(chǎn)額比，即DSB/SSB為6：1，說(shuō)明雙鏈斷裂是低能離子引發(fā)DNA鏈斷裂的主要形式。
- Methods Nick translation assay was used to detect the level of DNA strand break. 方法 用缺口翻譯技術(shù)檢測DNA鏈斷裂 ,用軟瓊脂克隆形成率評價(jià)細胞轉化。
- CAT and PARP participated in the induction of peroxidative adaptation to DNA strand break. CAT和PARP參與過(guò)氧化DNA斷裂的適應誘導。
- The results showed that BK chromosomes reveal a multiple double strand helical structure . 觀(guān)察到BK染色體具有多級雙股螺旋結構。
- DNA double strand breaks (DSBs) 雙鏈DNA斷裂
