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- Cell cycle is mainly regulated by cyclin, cyclin dependent kinase(CDK) and cyclin dependentkinase inhibitor (CDKI). 細胞周期主要是由細胞周期蛋白(cyclin)，細胞周期蛋白依賴(lài)性激酶(CDKs)和CDK抑制蛋白(CDKI)來(lái)調控的。
- Protein serine theronine phosphatase inhibitor or cyclin dependent kinase( CDK) inhibitors could abolish the enhancement. 而蛋白絲氨酸蘇氨酸磷酸酯酶抑制劑以及細胞周期蛋白依賴(lài)性激酶(DK)制劑可阻斷該凋亡敏感性增強效應。
- It is well known that cell cycle in eukaryotic cells is controlled by various complexes composed of cyclin and cyclin dependent kinase (CDK). 真核細胞周期是受細胞周期蛋白(cyclin)和細胞周期蛋白依賴(lài)激酶(cyclin dependent kinase,CDK)組成的蛋白復合體調控。
- There are many factors that regulate the proliferation and differentiation of cells. The major factors include cyclin, cyclin dependent kinase (cdk) and cyclin dependent kinase inhibitor (CDKI). 調節細胞增殖和分化的因素有許多種，其中主要有細胞周期蛋白(cyclin)、細胞周期蛋白依賴(lài)性激酶(cyclin dependent kinase，cdk)和細胞周期蛋白依賴(lài)性激酶抑制因子(cyclin dependent kinase inhibitor,CDKI)。
- Purpose To investigate the roles of cyclin dependent kinase (cdk) 2 and cdk4 in the pathogenesis of benign prostatic hyperplasia (BPH) and prostatic carcinoma (PC) and their relation to PCNA. 目的：探討細胞周期蛋白依賴(lài)性激酶cdk2和cdk4在前列腺增生（BPH）和前列腺癌（PC）的發(fā)生發(fā)展過(guò)程中作用及其與PCNA之間關(guān)系。
- In the recent years, cyclin, cyc-lin dependent kinase and cyclin dependent kinase inhibitor have important effect in cell cycle modulation. 近年來(lái)發(fā)現細胞周期素(Cyclin)、細胞周期蛋白依賴(lài)激酶(Cyclin dependent kinase，CDK)和細胞周期蛋白依賴(lài)性激酶抑制因子(Cyclin dependent kinase inhibitor，CKI)在真核生物細胞周期調控有重要作用。
- P21WAF1 is a kind of cyclin dependent kinase inhibitor, it can be bind to several kinds of cyclin/CDK compounds and arrest the cell cycle. P21~(WAF1)是一種CKI，它可與多種cyclin/CDK復合物結合，引起細胞周期阻滯。
- Objective To investigate roles of cyclin dependent kinase 4 (CDK4) in nordihydroguaiaretic acid (NDGA) induced inhibitory effect on proliferation of human malignant glioma cells. 目的 探討細胞周期蛋白依賴(lài)性蛋白激酶 4(CDK4)在去甲二氫愈創(chuàng )木酸 (NDGA)抑制人惡性膠質(zhì)瘤細胞系SHG 44細胞增殖中的作用。
- Objective: To study the relationship between cyclin dependent kinase 4 (CDK4),PTEN protein expression and carcinogensis、progression and recurrence of endometrial carcinoma . 目的：探討PTEN、CDK4蛋白表達與子宮內膜癌的發(fā)生、發(fā)展及復發(fā)的關(guān)系。
- Objective To investigate the role of proliferating cell nuclear antigen (PCNA) and cyclin dependent kinase 2 (CDK2) in inhibition of vascular smooth muscle cells (VSMCs) proliferation by gax gene. 目的 研究增殖細胞核抗原 (PCNA)和細胞周期蛋白依賴(lài)性激酶 2 (CDK2 )在gax基因抑制血管平滑肌細胞 (VSMC)增殖中的作用。
- ObjectiveTo explore the abnormalities of expression of p16,retinoblastoma(RB),cyclinD1,cyclin dependent kinase 4(CDK4)genes and the relationship between these abnormalities and the cell proliferation in glioblastomas(GBMs). 目的探討膠質(zhì)母細胞瘤中p16基因、視網(wǎng)膜母細胞瘤基因 (retinoblastomagene,RB)、細胞周期蛋白D1(cyclinD1)基因、細胞周期蛋白依賴(lài)性激酶 4 (cyclindependentkinase 4 ,CDK4 )基因表達的異常及其與細胞增殖活性之間的關(guān)系。
- Objective: To study the expression of cyclin dependant kinase 4(CDK4) protein in oral carcinogenesis. 目的：探討CDK4蛋白在口腔粘膜癌變過(guò)程中表達的變化規律。
- cyclin dependent kinase inhibitor CK1
- cyclin dependent kinase inhibitors CDK抑制蛋白
- Cyclin dependent kinase 4 (CDK4) 細胞周期蛋白依賴(lài)性激酶4
- Cell cycle cyclin dependent kinase inhibitors(CKIs) 細胞周期
- Methods Expressions of cyclin E and cyclin dependent kinases 2(cdk2)in 38 cases of lung cancer and 6 cases of normal lung tissues were examined by immunohistochemistry. 方法 :應用免疫組化方法檢測細胞周期蛋白E(cyclinE)和細胞周期蛋白依賴(lài)性激酶 2 (cdk2 )在 38例肺癌和 6例正常肺組織中的表達狀況。
- Objective To study the role of cycline dependent kinase 4(CDK4) in the malignant transformation of human fetal lung diploid fibroblast cell(2BS) induced by silica. 目的 探討細胞周期蛋白依賴(lài)激酶K4(CDK4)在石英致人胚肺成纖維細胞(2BS)惡性轉化過(guò)程中所起的作用,為石英致癌機制提供理論依據。
- Formation, activition and degradation of cyclin - dependent kinase(CDK) and cyclin complex are the main molecular foundation. 其中細胞周期素依賴(lài)性激酶(cyclin-dependent kinase，CDK)與細胞周期素(cyclin)復合體的形成、激活與失活是細胞周期調控的主要分子基礎。
- cyclin dependent kinase(CDK) 細胞周期蛋白依賴(lài)激酶
