ObjectiveTo explore the abnormalities of expression of p16,retinoblastoma(RB),cyclinD1,cyclin dependent kinase 4(CDK4)genes and the relationship between these abnormalities and the cell proliferation in glioblastomas(GBMs).
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- 目的探討膠質(zhì)母細胞瘤中p16基因、視網(wǎng)膜母細胞瘤基因 (retinoblastomagene,RB)、細胞周期蛋白D1(cyclinD1)基因、細胞周期蛋白依賴(lài)性激酶 4 (cyclindependentkinase 4 ,CDK4 )基因表達的異常及其與細胞增殖活性之間的關(guān)系。
