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- Objective: To investigate the relationship between the cyclin kinase inhibitor P27 and the effect of low protein diet on the renal hypertrophy of diabetic glomerulus. 目的:探討低蛋白飲食對糖尿病腎病大鼠腎臟肥大的影響及其與腎小球周期素激酶抑制劑P27的關(guān)系。
- Keywords EGCG;Mesangial cell;Diabetic nephropathy;Cyclin kinase inhibitor p27; 周期素激酶抑制劑;系膜細胞;糖尿病腎病;
- Keywords cell cycle regulatory protein;cyclin kinase inhibitor;glomerulonephritis;mesangial proliferative; 細胞周期蛋白類(lèi);周期素激酶抑制劑;腎小球腎炎;系膜增生性;
- Cyclin Kinase Inhibitor P21 細胞周期蛋白依賴(lài)性激酶抑制劑P21
- In the recent years, cyclin, cyc-lin dependent kinase and cyclin dependent kinase inhibitor have important effect in cell cycle modulation. 近年來(lái)發(fā)現細胞周期素(Cyclin)、細胞周期蛋白依賴(lài)激酶(Cyclin dependent kinase，CDK)和細胞周期蛋白依賴(lài)性激酶抑制因子(Cyclin dependent kinase inhibitor，CKI)在真核生物細胞周期調控有重要作用。
- P21WAF1 is a kind of cyclin dependent kinase inhibitor, it can be bind to several kinds of cyclin/CDK compounds and arrest the cell cycle. P21~(WAF1)是一種CKI，它可與多種cyclin/CDK復合物結合，引起細胞周期阻滯。
- P 27Klpl is a kind of cyclin dependnt kinase inhibitor (CKI) and it can regulate cell cycle through restraining cyclin and cyclin dependnt kinase (CDK). _p27蛋白是一種細胞周期蛋白依賴(lài)性激酶抑制劑(cyclin dependnt助興大嘗醫筍朦碩生~研羌生.;早業(yè)訟戈
- The factors that regulate the cell cycle include Cyclin, Cyclin-dependent kinase(CDK), Cyclin-dependent kinase inhibitor(CKI). CyclinDl is the major control switches in the G1 phase. 參與細胞周期調控的蛋白主要有：細胞周期蛋白(Cyclin)、細胞周期蛋白依賴(lài)性激酶(Cyclin-dependent kinase，CDK)、細胞周期蛋白依賴(lài)性激酶抑制因子(Cyclin-dependent kinase inhibitor，CKI)。
- Is PDGF tyrosine kinase inhibitor effective in pancreatic cancer? PDGF受體酪氨酸激酶抑制劑在胰腺癌中是否有作用?
- P27Kipl is a multifunctional cyclin depedent kinase inhibitor (CKI) that was found recently, and to be regarded as a negative regulative restraining gene of cyclin depedent kinase( CDK) for cell cycle. P27Kipl是近年發(fā)現的一個(gè)多功能細胞周期蛋白依賴(lài)激酶抑制劑(CKI),作為CDK的抑制因子對細胞周期實(shí)行負調控。
- There are many factors that regulate the proliferation and differentiation of cells. The major factors include cyclin, cyclin dependent kinase (cdk) and cyclin dependent kinase inhibitor (CDKI). 調節細胞增殖和分化的因素有許多種，其中主要有細胞周期蛋白(cyclin)、細胞周期蛋白依賴(lài)性激酶(cyclin dependent kinase，cdk)和細胞周期蛋白依賴(lài)性激酶抑制因子(cyclin dependent kinase inhibitor,CDKI)。
- Sunitinb is a novel multitargeted receptor tyrosine kinase inhibitor. 蘇尼替尼是一種新型的多靶點(diǎn)酪氨酸激酶抑制劑。
- cyclin dependent kinase inhibitor CK1
- The progress in tyrosine kinase inhibitor has been reviewed, including the chemical structures and the pharmacophore models. 本文綜述了近年來(lái)酪氨酸激酶抑制劑的研究進(jìn)展，包括抑制劑的結構和與激酶作用的藥效團模型。
- And PI3 kinase inhibitor LY294002 blocked the differentiation of ADAS cells into endothelial cells in vitro. 利用信號通路特異性抑制劑抑制實(shí)驗，提示PI3K在A(yíng)DAS細胞向內皮細胞分化中
- Gefitinib, the first EGFR tyrosine kinase inhibitor put into clinical trial, was put into market in Japan in 2002. 吉非替尼是EGFR酪氨酸激酶抑制劑中最早進(jìn)入臨床試驗的口服藥物，2002年首次于日本上市。
- EGFR tyrosine kinase inhibitor is an investigative hot spot in targeted therapy of non-small cell lung cancer (NSCLC). 摘要EGFR靶向抑制劑，是目前NSCLC靶向治療的研究熱點(diǎn)之一。
- Gefitinib (Iressa, ZD1839), a specific tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR), is a novel molecular-targeting antineoplastic agent. 摘要吉非替尼是一種新型的分子靶向抗癌藥物，它選擇性抑制表皮生長(cháng)因子受體酪氨酸激酶而發(fā)揮作用。
- The activity of cyclin - Cdk complexes is affected by cyclin - dependent kinase inhibitors including P27kip1. P27kIp1 protein binds to cyclin D - Cdk4, cyclin E - Cdk2 and cyclinA - Cdk2 complex inhibiting their activities during the cell cycle. 目前發(fā)現的CDKI按結構和功能的不同可分成兩大類(lèi)：一類(lèi)為Cip/Kip(CDK-interacting protein/kinase inhibition protein)，包括p21~(Cip1)、p27~(kip1)、p57~(kip2)等。
- Objective To assess the effect of tyrosine kinase inhibitor (2,5-MC) on the inhibition of in-stent inti-mal hyperplasia. 目的評估酪氨酸蛋白激酶抑制劑2,5-MC抑制支架植入術(shù)后內膜增殖的效果。
