The activity of cyclin - Cdk complexes is affected by cyclin - dependent kinase inhibitors including P27kip1. P27kIp1 protein binds to cyclin D - Cdk4, cyclin E - Cdk2 and cyclinA - Cdk2 complex inhibiting their activities during the cell cycle.
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美
- 目前發(fā)現的CDKI按結構和功能的不同可分成兩大類(lèi)：一類(lèi)為Cip/Kip(CDK-interacting protein/kinase inhibition protein)，包括p21~(Cip1)、p27~(kip1)、p57~(kip2)等。
