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- CDK2, one of the important members in CDK family, directly regulates the critical steps in cell cycle progression including transition of G1/S checkpoint, DNA replication and centrosome d. CDK2是CDK家族中的重要成員，它直接參與細胞周期G_1／S限制點(diǎn)、S期DNA復制和中心體復制的調節，它的活性和功能調節是細胞周期運轉的的關(guān)鍵環(huán)節之一，與細胞癌變有著(zhù)十分密切的關(guān)系。
- Hypothesize how a protein might possibly act as a primer for DNA replication. 試想一種蛋白質(zhì)怎樣能成為DNA復制所用的引物。
- DNA damage by mutagens has very serious consequences for DNA replication. 試比較切除修復和光復活機制是如何清除由紫外線(xiàn)誘導形成的嘧啶二聚體的？
- When SV40 enters a cell, it produces T antigen, which functions to trigger viral DNA replication. 當SV40病毒進(jìn)入細胞時(shí)會(huì )產(chǎn)生T抗原，它的作用是觸發(fā)病毒DNA繁殖。
- Chromosomal DNA replication starts at the sites called Origins by forming replication forks. 染色體DNA的復制是由許多復制起點(diǎn)處形成的起始復制叉開(kāi)始的。
- DNA replication is one of the crucial steps to normal cell division.This process is regulated elaborately. DNA復制是細胞分裂的中心環(huán)節之一,在細胞周期中受到嚴謹的調控。
- This paper summarizes the roles of minichromosome maintenace proteins in DNA replication. 本文就微小染色體維持蛋白在復制中的作用簡(jiǎn)單綜述。
- Vaccinia virus B1R gene product acts as protein kinase with an essential role in viral DNA replication. 牛痘病毒B1R基因產(chǎn)物是一個(gè)蛋白激酶，在病毒的DNA復制中起著(zhù)重要作用。
- PURPOSE Minichromosome maintenance proteins(MCMs) are members of the prereplicative complex that is essential for eukaryotic DNA replication. 目的 微型染色體維持蛋白(minichromosome maitenance proteins，MCMs)已經(jīng)被證明為真核細胞復制前復合體的必需組成成分，是真核細胞DNA復制起始所必需的。
- This family expresses periodically to regulate DNA replication and ensure DNA replication once and only once in every cell cycle. 該蛋白家族呈周期性表達,調節DNA復制,使得每個(gè)細胞周期的DNA復制一次且僅有一次。
- Additionally, p21 can act as an inhibitor of DNA replication through its association with PCNA, a protein required for processive DNA synthesis. 它還可以通過(guò)C端與PCNA相互作用，阻斷PCNA活化DNA聚合酶的活性從而抑制DNA的合成，使細胞周期停滯。
- Most of our knowledge about initiation of eukaryotic DNA replication are derived from the study of budding yeast Saccharomyces cerevisiae. 真核生物DNA復制起始機制的大部分知識主要是在芽殖酵母中獲得的。
- The nuclear matrix provides structural support for several processes such as DNA replication,transcription,and RNA splicing and transport. 細胞惡變以及腫瘤細胞由低度變成高度惡性的過(guò)程中,都會(huì )發(fā)生惡性轉化。
- Novak, B. and J. J. Tyson. "Modeling the Control of DNA Replication in Fission Yeast." Proc. Natl. Acad. Sci. USA 94 (1997): 9147-52. “控制分裂酵母菌的DNA復制模型”。美國期刊“國家學(xué)院科學(xué)論文集”第94卷。第9147到9152頁(yè)。
- These results can help us to learn the composition of CTF/NF-1 and explain the complicated functional mechanism of CTF/NF-1 in the process of DNA replication and transcription. 這一結果對闡明CTF/NF－1復雜多樣的調控機制及其組成種類(lèi)有重要意義。
- GMA had positive results in Ames test and mouse bone marrow micronucleus test. GMA bound with DNA convalently, induced UDS and inhibited DNA replication in lymphocyte in vitro. GMA在A(yíng)mes試驗和小鼠骨髓微核試驗得到陽(yáng)性結果,GMA可與DNA共價(jià)結合,在體外淋巴細胞培養誘導UDS和抑制DNA復制。
- Results The overall positive rate of MSI in CRC were 47.2%(25/53). 23 case(23/53,43.4%) have MSI at 2 or more than 2 loci which showed DNA replication error(RER)-positive. 結果53例大腸癌中25例存在微衛星不穩定;總陽(yáng)性率為47.;2%25;其中23例存在2個(gè)以上位點(diǎn)的MSI;呈復制誤差陽(yáng)性(RER陽(yáng)性);占43
- Further studies showed that DNA replication fidelity is decreased and there is an alteration of DNA polymerase spectrum when mammalian cells are attacked by MNNG. 因此，我們推測，哺乳細胞中低保真度的跨損傷DNA聚合酶可能參與了MNNG誘導的哺乳細胞非定標突變。
- Irrespective of how DNA replication stress is induced,the collapse of DNA replication forks occurs preferentially at specific chromosomal locicalled common fragilesites(23). 不管DNA復制應答是怎樣被誘導的，DNA復制叉的崩潰會(huì )有選擇性的發(fā)生在染色體的易碎位點(diǎn)（23）。
- Modifications of DNA by endogenous or environmental reactive species could lead to mutation during DNA replication, which is the initiation step of carcinogenesis. 摘要去氧核醣核酸(DNA)被體內或環(huán)境中具反應性物種修飾后會(huì )在DNA復制時(shí)導致基因突變，為細胞癌化的第一步。
