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- AcrAB外流泵系統的合成有多重耐藥調節子 (marRAB)調控 ,AcrAB與多種抗生素的耐藥有關(guān)。 拓撲異構酶 (topoisomerase)的突變主要與氟喹諾酮類(lèi)藥物的耐藥性有關(guān) ,突變主要發(fā)生在gyrA ,parC基因上The acrAB locus encode the efflux pump AcrAB,which confers multidrug tolerance,controlled by the regulon marRAB. Mutation in the gyrase and topoisomerase IV lead to fluoroquinolones resistance, mainly arise in gyrA and parC genes.
