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- Protein tyrosine nitration is a biomarker of NO-dependent oxidative stress. 摘要蛋白質(zhì)酪氨酸硝化是一氧化氮依賴(lài)的氧化應激的生物標志。
- However, the role of specific protein tyrosine phosphatases (PTPs) in these pathways is unknown. 然而，在這些途徑中，特異性酪氨酸蛋白激酶的作用尚未清楚。
- OBJECTIVE:To discuss the progress and the clinical application evaluation of protein tyrosine kinase(PTK) inhibitors. 目的:探討酪氨酸激酶抑制劑的進(jìn)展與臨床應用評價(jià)。
- Abstract: Protein tyrosine nitration is an important posttranslational modification involving a variety of diseases. 文章摘要: 蛋白質(zhì)酪氨酸硝基化是一種重要的蛋白質(zhì)翻譯后修飾，與多種病癥相關(guān)。
- Protein tyrosine nitration is an important posttranslational modification involving in a variety of diseases. 蛋白質(zhì)酪氨酸硝基化是一種重要的蛋白質(zhì)翻譯后修飾，與多種病癥相關(guān)。
- Protein tyrosine kinases play an important role in signal transduction pathways in regulating a number of cellular functions. 蛋白質(zhì)酪氨酸在一系列細胞活動(dòng)的信號轉導途徑中起著(zhù)重要的作用。
- Objective To approach the mechanism of action of anticancer and the investigation progress of protein tyrosine kinase (PTK). 摘要目的探討蛋白酪氨酸激酶抑制劑抗腫瘤作用機理及其研究進(jìn)展。
- Objective To approach the mechanism of action of anticancer and the investigation progress of protein tyrosine kinase(PTK). 目的探討蛋白酪氨酸激酶抑制劑抗腫瘤作用機理及其研究進(jìn)展。
- SHP-2, a cytoplasmic SH2 domain containing protein tyrosine phosphatase is involved in the signaling pathways of a variety of growth factors and cytokines. SHP-2，一種含有SH2區域的胞漿蛋白酪氨酸磷酸酶，參與了各種生長(cháng)因子和細胞因子的信號傳導過(guò)程。
- Protein tyrosine nitration is an important selective post-translational modification, and the product, 3-nitrotyrosine, has been utilized as a biomarker of tissue and cell injury. 摘要蛋白質(zhì)酪氨酸硝化是一種重要的蛋白質(zhì)翻譯后的選擇性修飾，其產(chǎn)物3-硝基酪氨酸可以作為檢測細胞和組織損傷的一個(gè)生物標志。
- Receptor tyrosine kinase (RTK), a membrane receptor superfamily with intrinsic protein tyrosine kinase activity, has many members and complicated signal transduction pathways. 摘要受體酪氨酸激酶是一個(gè)具有內在酪氨酸蛋白激酶活性的膜受體超家族，成員眾多，信號轉導通路復雜多樣。
- Obejective To investigate the 387 Pro Leu polymorphism in protein tyrosine phosphastase 1B (PTP 1B) and its relationship with the risk of type 2 diabetes mellitus(T2DM) in Chinese population. 目的 探討蛋白酪氨酸磷酸酶 1B(proteintyrosinephosphastase 1B ,PTP 1B)基因 387位編碼子Pro Leu多態(tài)性與 2型糖尿病 (T2DM )的關(guān)系。
- DDR2 is a newly identified receptor protein tyrosine kinase, which is composed of three parts: DR region on the N terminus, a long justatransmembrane region (JM) between DR region and transmembrane region, and intracellular region in cytoplasma. DDR2是一類(lèi)新發(fā)現的受體型蛋白酪氨酸激酶，其分子結構由三部分組成：一是N端的DR區，二是在DR與跨膜區之間的很長(cháng)的鄰跨膜區(justatransmembrane region，JM)，三是在胞漿內的胞內區。
- Protein tyrosine phosphatases (PTPs) played crucial role in physiology, participate in such work as cell growth, differentiation, and metabolism. Here we developed three activity probes for PTPs. 摘要:PTP在生理方面扮演著(zhù)相當重要的角色，參予了細胞生長(cháng)、分化、代謝以及訊息傳遞等工作，因此本研究針對PTP設計并合成出活性標示分子。
- The conservation in sequence and structure of protein tyrosine phosphatases has been analyzed by aligning their sequences and superposed their three dimensional topological structures. 以蛋白質(zhì)酪氨酸磷酸酶為模型，通過(guò)序列和結構的比較，對蛋白質(zhì)序列、結構的保守性與其功能和進(jìn)化的關(guān)系問(wèn)題進(jìn)行了研究。
- ABSTRACT STI571 is one of the target drugs to Bcr/Abl oncoprotein.It is a special inhibitor to the activation of protein tyrosine kinase by interrupting phosphorylation of substrate. 摘 要 STI571 是一種針對Bcr/Abl基因表達產(chǎn)物的靶向治療藥物，可以阻止底物的酪氨酸殘基磷酸化，發(fā)揮特異性酪氨酸蛋白激酶活性抑制作用，臨床研究結果證明對慢性粒細胞白血病的療效顯著(zhù)優(yōu)于干擾素及其它化療藥物。
- The advances made in the new compounds identified as Protein Tyrosine Phosphatases 1B (PTP1B) inhibitors recently and their structure-activity relationship were reviewed in this paper. 介紹了最近幾年來(lái)關(guān)于酪氨酸蛋白磷酸酯酶1B作用的機制以及通過(guò)各種途徑發(fā)現的結構新穎的小分子抑制劑的構效關(guān)系研究進(jìn)展。
- tyrosine sulfation 酪氨酸硫酸化
- HTS model for protein tyrosine kinase inhibitors 酪氨酸蛋白激酶抑制劑的高通量篩選模型
