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- It also indicates that TBA-DNA adducts can be partly eliminated by DNA repair. 這表明，TBA與小鼠肝/肺DNA加合物在小鼠體內能得到一定的修復。
- Cancer genetics, somatic mutagenesis, DNA repair, genomics and molecular medicine. 腫瘤發(fā)生的遺傳機制；體細胞突變的發(fā)生機制；DNA修復，基因組學(xué)與分子醫學(xué)。
- It is caused by an inherited weakness in one gene that controls DNA repair in other genes. 這是因為某種基因比較脆弱，使得DNA無(wú)法修復其他基因。
- At the same time, cerebral ischemia can activate a complex network of DNA repair tocounteract neuronal DNA damage. 然而缺血在導致DNA損傷的同時(shí)，還激活自身的DNA修復系統。
- We calculated lymphocyte post irradiation viability ratio to detect the defection of DNA repair after DN... 即基因修復缺陷可能是帕金森病發(fā)病機制的重要環(huán)節。
- Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. 聚（ADP -核糖）依賴(lài)的DNA修復調節的染色質(zhì)重塑酶ALC1。
- DNA repair pathways can enable tumor cells to survive DNA damage induced by anti-tumor drugs such as alkylating agents. DNA損傷修復能夠使腫瘤細胞耐受化療藥物造成的DNA損傷而存活,因此,調節某種特殊的DNA修復路徑可以增強化療藥物的療效。
- P63 may also co-ordinate DNA repair in eggs with fewer than three breaks, says Dr McKeon. P63可能在卵細胞三次分裂以前對DNA的修復起到協(xié)調作用，McKeon稱(chēng)。
- The activity of DNA repair enzyme reduction may involve the mechanism of apoptotic neuron death after ischemia/reperfusion. （2）大鼠腦缺血/再灌注后缺血區神經(jīng)元凋亡與神經(jīng)元DNA修復酶活性下降有關(guān)。
- PCNA also plays an important role in the DNA repair of neuron,gliocyte proliferation,and cell apoptosis after cerebral ischemia. 腦缺血后出現神經(jīng)元細胞DNA修復、膠質(zhì)細胞增生以及細胞凋亡等,PCNA在其中發(fā)揮了重要作用,因此受到人們的廣泛關(guān)注。
- Therefore, modulating specific DNA repair pathways might prove efficacious when used in combination with DNA-damaging chemotherapeutic drugs. 另外,有些DNA修復路徑在一些腫瘤細胞中是失活的。
- Some DNA repair genes are irreversibly damaged by smoking, and smoking also switched off genes that help combat lung cancer development. 而吸煙將不可逆的破壞一些DNA修復基因，并關(guān)閉一些對抗肺癌的基因。
- Gene expression is highly regulated and interconnected to processes like mRNP processing, mRNA export as well as to DNA repair and replication. 專(zhuān)有名詞的識別在資訊萃取的步驟中扮演著(zhù)重要的角色，文件中資訊的描述，皆由專(zhuān)有名詞引述出資訊的所在。
- In addition, alterations in DNA repair pathways that arise during tumour development can make some cancer cells reliant on a reduced set of DNA repair pathways for survival. 此外，在腫瘤發(fā)展過(guò)程中出現的DNA修復通路的轉變可以使一些癌細胞依賴(lài)于DNA修復通路的減少而得以生存。
- In a word, the FANCD2 activity adjusted exquisitely by ubiquitination and/or deubiquitination in vivo may co-regulate the FA pathway involving in variant DNA repair pathway. 機體很可能在不同信號通路對FANCD2泛素化/去泛素化的精細調節下，調控FA途徑參與不同的DNA修復過(guò)程。
- Most members of the XRCC genes family participated in several DNA repair pathways, including base excision repair, homologous recombination repair and non-homologous end joining. 目前已鑒定的這一基因家族的多數成員均參與幾種重要的DNA修復途徑,包括堿基切除修復、同源重組修復和非同源末端重接。
- Histone lysine methylation has important functions in many biological processes that include gene expression,X-chromosome inactivation,gene imprinting and DNA repair. 組蛋白賴(lài)氨酸甲基化作為共價(jià)修飾的一種在基因表達調控、X染色體失活、基因組印跡、DNA修補等生物學(xué)過(guò)程中起重要作用。
- One line of eidence supporting the connection is that defects in certain genes needed for DNA repair produce maladies that mimic those of accelerated aging. 支持這種關(guān)系的證據是需要修復的特定基因的損傷產(chǎn)生疾病例如加速衰老。
- PCNA also plays an important role in the DNA repair of neuron,gliocyte proliferation,and cell apoptosis after cerebral ischemia.So it attracts more attention. 腦缺血后出現神經(jīng)元細胞DNA修復、膠質(zhì)細胞增生以及細胞凋亡等，PCNA在其中發(fā)揮了重要作用，因此受到人們的廣泛關(guān)注。
- The main mechanism of cisplatin is tumor cells death by damaging the DNA.The resistance to cisplatin is associated with the cell's increased ability of DNA repair. 順鉑的主要藥理機制是損傷細胞DNA,腫瘤細胞DNA修復能力增強則會(huì )導致其對順鉑耐藥。
