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- The androgen receptor(AR)belongs to the steroid receptor family,which is a part of the large nuclear receptor superfamily. 雄激素受體(AR)屬于核受體超家族中的類(lèi)固醇受體。
- Peroxisome proliferator-activated receptor(PPAR) is a transcription factor,belongs to the nuclear receptors family,plays a critical role in the pathophysiology of cardiac hypertrophy. 過(guò)氧化物酶體增殖激活受體(PPAR)是甾體激素受體超家族的新成員,能被脂肪酸以及外源性過(guò)氧化物酶體增殖劑激活,而調控參與脂類(lèi)代謝的某些酶的基因表達。
- Abstract:The peroxisome proliferator activated receptor (PPAR) belongs to a large family of nuclear receptors. PPAR基因是近年發(fā)現的與脂類(lèi)代謝有重要關(guān)聯(lián)的核受體基因。
- Probably the new nuclear receptor ligands such as FXR ligand will be the next compound. 新的核受體配體很可能成為下一代化合物，如FXR配體。
- MC5R gene is one of the Melanocortin receptor family, and is ralated to animal obsity. 摘要MC5R基因是黑素皮質(zhì)素受體家族的一員，與動(dòng)物肥胖相關(guān)。
- Objective To determine the ETO interaction domain of nuclear receptor co repressor (N CoR) for abolishing the biological function of AML1 ETO. 目的 為消除急性髓系白血病標志基因AML1/ETO的活性 ,確定核受體輔助抑制因子(nuclearreceptorco repressor,N CoR)與ETO基因相互作用的活性部位。
- Androgen receptor belongs to the nuclear receptor superfamily and is a ligand-dependent transcription regulator, which can be activated by androgen. 雄激素受體屬于核受體超家族，為配體依賴(lài)性基因轉錄因子，與雄激素結合后被激活。
- The Nuclear Receptor Coactivator AIB1 Mediates Insulin-like Growth Factor I-induced Phenotypic Changes in Human Breast Cancer Cells. 主要學(xué)術(shù)內容和意義：核受體輔激活子AIB1（乳腺癌中擴增）在人類(lèi)乳腺癌細胞中通過(guò)雌激素信號過(guò)表達。
- GnRH-R belongs to the G protein coupled receptor family, and it is consisted of a polypeptide chain containing 7 transmembrane domains. The GnRH-R encodes 327/328 amino acids. 研究結果提示，GnRH－R屬于G蛋白偶聯(lián)受體家族，由包含7次跨膜結構域的單一多肽鏈構成，編碼327或328位氨基酸。
- This article reviewed the advance in study on nuclear receptor mediating cell proliferation differentiation and apoptosis. 現就核受體介導細胞增殖、分化與凋亡的作用機制研究進(jìn)展做一綜述。
- The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression. HR蛋白是細胞核受體輔阻遏物的發(fā)現證明HR蛋白是通過(guò)在毛發(fā)周期中調節基因表達來(lái)發(fā)揮作用的。
- In this article, we reviewed the research advancement in the signal transduction pathway of nuclear receptor and membrane receptor during the activation of hepatic stellate cells. 本文就肝星狀細胞激活過(guò)程中一些重要的膜受體、核受體信號轉導途徑及其研究進(jìn)展作一綜述。
- Recent work linking these pathways in epithelial stem cell differentiation has come from studies analyzing the in vivo function of the nuclear receptor corepressor, Hairless (HR). 近來(lái)的有關(guān)表皮干細胞分化的途徑的工作基于分析細胞核受體輔阻遏物HR的體內作用的研究。
- Abstract ：Nuclear receptor (NR) is a ligand-dependent transcriptional factor which plays an important role in the metabolism of xenobiotics and endobiotics. 摘 要 ：核受體是一種配體依賴(lài)性轉錄因子，在外源性物質(zhì)和內源性物質(zhì)的代謝中具有重要作用。
- Until now, many nuclear receptor coactivators were cloned including RIP 140, CBP/P300, SRC/pl60, CARM-1, TRAP/DRIP, and the newly discovered SRA (a small RNA molecular serving as a coactivator). 迄今已分離鑒定出大量的核受體輔活化子，如RIP140、CBP/P300、SRC/p160家族、CARM-1、TRAP/DRIP等，包括最近發(fā)現的SRA(一種有輔活化子功能的RNA)。
- Previously we found that DHF patients’ sera contain higher titer against TNF receptor families, including TRAIL-R1 (DR4). 先前我們的研究中發(fā)現DHF病人血清中能交互作用到腫瘤壞死因子群中的DR4。
- Estrogen receptor (ER), an important transcription factor belonging to the nuclear receptor superfamily, plays a key role in reproductive, cardiovascular and central nervous systems and bone tissue. 摘要雌激素受體屬于核受體超家族成員，是一類(lèi)重要的核轉錄因子，它在生殖系統、骨組織、心血管和中樞神經(jīng)系統中發(fā)揮著(zhù)重要的生理作用，是治療骨質(zhì)疏松和乳腺癌的重要藥物作用靶標。
- Objective To investigate the localization and expression pattern of nuclear receptor NR4A1 protein in follicle and corpus luteum cells at different estrous stages in cycling female SD rat. 目的：通過(guò)研究核受體NR4A1蛋白在正常雌性SD大鼠不同卵巢功能周期的不同發(fā)育階段卵泡及黃體細胞中的表達，推測其在卵泡發(fā)育中的生物學(xué)作用。
- She only unbends in the family circle. 她只在家庭環(huán)境里才不拘束。
- Estrogen receptor(ER),an important transcription factor belonging to the nuclear receptor superfamily,plays a key role in reproductive,cardiovascular and central nervous systems and bone tissue. 雌激素受體屬于核受體超家族成員,是一類(lèi)重要的核轉錄因子,它在生殖系統、骨組織、心血管和中樞神經(jīng)系統中發(fā)揮著(zhù)重要的生理作用,是治療骨質(zhì)疏松和乳腺癌的重要藥物作用靶標。
