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- Abnormal deposition of senile plaques (SP), neurofibrillary tangles (NFT) , synapse loss and neuronal cell death are pathological changes which are commonly found in AD patient’s brain. AD患者腦中典型的病理改變包括老年斑(SP)的異常沉積、神經(jīng)原纖維纏結(NFT)、突觸喪失以及神經(jīng)元的死亡。
- Alzheimer s disease(AD)is a progressive neurodegenerative disease.AD is characterized by recent memory impairment.Its pathological characteristics are senile plaque and neurofibrillary tangles(NFT). 阿爾茨海默病(AD)是以近期記憶障礙為主要臨床癥狀,以老年斑及神經(jīng)纖維纏結為主要病理改變的進(jìn)行性神經(jīng)變性疾病。
- Human apoE4 has been found in senile plaques (SPs) and neurofibrillary tangles (NTFs) in AD brains. 研究進(jìn)一步表明，AD患者腦內的老年斑和神經(jīng)原纖維纏結中存在有較多的載脂蛋白E4(apolipoprotein E4,apoE4)。
- Segmentation of senile plaques and neurofibrillary tangles is crucial to pathological analysis of Alzheimer's disease. 老年斑和神經(jīng)元纏結的分割提取對于阿爾茨海默癥病理研究有重要的意義。
- Upon autopsy, the presence of amyloid plaques and neurofibrillary tangles is used to positively diagnose Alzheimer's disease. 經(jīng)過(guò)尸體解剖，淀粉質(zhì)色斑的出現和神經(jīng)原纖維的混亂狀態(tài)被用來(lái)確診阿茲海默癥。
- Definitie diagnosis requires postmortem identification of amyloid plaques and neurofibrillary tangles linked to the disease. 最終確診需要尸檢發(fā)現與本病相關(guān)的淀粉樣蛋白斑及神經(jīng)纖維纏結。
- Neurofibrillary tangles develop when microtubule tau proteins become hyperphosphorylated and aggregate within the neuronal cells. 這些(神經(jīng)細胞內)神經(jīng)纖維糾結，會(huì )分解瓦解神經(jīng)元沿軸突運輸分子的能力。
- In Alzheimer's disease brain cells degenerate, brain mass shrinks and characteristic neurofibrillary tangles and neural plaques are seen post mortem. 而在早老性癡呆癥患者死亡后檢驗發(fā)現有腦細胞退化、腦組織縮小、典型的神經(jīng)原纖維糾結及神經(jīng)斑塊等現象。
- To his surprise, Barrio found that FDDNP had a specific affinity for the neurofibrillary tangles and beta-amyloid plaques found in the brains of Alzheimer's patients. 參與研究的人員是核醫學(xué)專(zhuān)家，他們使用放射性化合物對人體內部組織進(jìn)行造影。為此，他們設計和建立了一種叫做FDDNP的分子。
- Here are neurofibrillary tangles in neurons of a patient with Alzheimer's disease. The cytoskeletal filaments are grouped together in the elongated pink tangles. 圖示阿爾茨海默病人神經(jīng)原纖維排列紊亂。細胞骨架微絲雜亂的聚集在變長(cháng)（箭頭示）的粉紅色區域中。
- Here are neurofibrillary tangles in neurons of a patient with Alzheimer's disease.The cytoskeletal filaments are grouped together in the elongated pink tangles. 圖示：阿爾茨海默病神經(jīng)原纖維纏結細胞骨架微絲雜亂的聚集在變長(cháng)（圖示）的粉紅色區域中。
- Firstly,a modified fuzzy C means method is used on the RGB color space to identify senile plaques and neurofibrillary tangles in microscopic image of the hippocampus separately. 利用改進(jìn)的模糊C均值算法對彩色圖像的顏色信息進(jìn)行聚類(lèi),分別提取了老年斑和神經(jīng)元纖維纏結目標。
- The basic principles of Al harming to intellect of human were studied.The results show that Al can enter cerebrum and combine with brain neurofibril to form neurofibrillary tangles and senile spots. 鋁對人類(lèi)智能危害的基本原理是鋁可進(jìn)入大腦，與腦神經(jīng)結合形成腦組織神經(jīng)原纖維纏結和老年斑。
- Keywords Alzheimer s disease;nerve growth factor;neurofibrillary tangles; 阿爾茨海默病;神經(jīng)生長(cháng)因子;神經(jīng)原纖維纏結;大鼠;
- Keywords Alzheimer s disease;Receptor;complement;Neurofibrillary tangles; 阿爾茨海默病;受體;補體;神經(jīng)原纖維纏結;
- One key issue is when to do NFT? 一個(gè)關(guān)鍵的問(wèn)題是何時(shí)進(jìn)行非功能性測試。
- The relationships between senile plaques, neurofibrillary tangles and sulfated polysaccharides 老年斑、神經(jīng)元纖維纏結與硫酸多糖
- Keywords Ubiquitin;Neurofibrillary tangles;Senile plaques;Hippocampus;Alzheimer disease; 關(guān)鍵詞泛素;神經(jīng)原纖維纏結;衰老斑;海馬;阿爾茨海默病;
- Keywords nerve growth factor;Alzheimer s disease;neurofibrillary tangles;choline acetyltransferase;rat; 神經(jīng)生長(cháng)因子;阿爾茨海默病;神經(jīng)原纖維纏結;膽堿乙?；D移酶;大鼠;
- Expression of ubiquitin in neurofibrillary tangles and senile plaque neurites in hippocampal formation of Alzheimer's disease brain 泛素在阿爾茨海默病神經(jīng)原纖維纏結和老年斑中的表達
