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- Objective To select high Lovastatin producing microbial breed by space flight. 目的選育高產(chǎn)洛伐他汀的紅曲霉菌菌株。
- Objective:To clinically observe the effect of lovastatin on patients with unstable angina pectoris(UA). 目的:探討洛伐他汀對不穩定性心絞痛(UA)患者的血脂、心臟缺血事件發(fā)生情況的影響。
- Methods 135 patients with hyperlipidemia were randomly allocated to two groups: Lovastatin group and XUEZHIKANG group. 方法將135例老年高脂血癥患者隨機分為洛伐他汀組和血脂康組；
- Objective To review the advances on lovastatin fermentation by Aspergillus terrus. 目的綜述土曲霉洛伐他汀發(fā)酵研究的進(jìn)展。
- The formula of fermentation medium of lovastatin form US patent 5409820 had been Optimized by Uniform Design Method. 應用均勻設計優(yōu)選試驗方法，采用國產(chǎn)原料，對洛伐他汀生產(chǎn)用發(fā)酵培養基配方進(jìn)行了優(yōu)化，取得了比較好的結果。
- HZ-818 wass selected as the adsorbent for isolating lovastatin from the filtered fermentation broth. 國產(chǎn)HZ-818作為分離純化洛伐他汀的吸附劑；
- Different concentrations of lovastatin had obvious inhibitive effects on the proliferation of RMC compared with control group(P<0.01). 不同濃度洛伐他汀對大鼠系膜細胞增殖均有明顯的抑制作用;與對照組比較有明顯差異(P<0.;01)。
- Conclusion With the advances of basic research about fungi producing lovastatin in the molecule and cell level,the optimization of lov... 結論隨著(zhù)洛伐他汀產(chǎn)生菌的分子、細胞水平基礎研究的加強,其發(fā)酵工藝的優(yōu)化將更有意義。
- Abstract: Objective To isolate and purify lovastatin from fermentation broth of Aspergillus terreus by macroporous adsorptive resins. 摘要：目的 用大孔吸附樹(shù)脂法分離純化洛伐他汀，提高洛伐他汀成品收率，適應工業(yè)化生產(chǎn)的需要。
- Ultraviolet spectrometry and HPLC were used to determine the content of Lovastatin capsule.In the meantime,we compared the results by the two means. 用紫外分光光度法測定洛伐他汀膠囊的含量,并將測定結果與高效液相色譜法的測定結果進(jìn)行比較。
- In the process of manufacturing Lovastatin Tablets, two kinds of refuses, fermentation refuse and refining refuse, are produced. 摘要 洛伐他汀生產(chǎn)過(guò)程中產(chǎn)生發(fā)酵渣和提煉渣。
- After flight, the strain was rejuvenized, segregated and selected.The content of Lovastatin produced in the solid fermentation was examined. 對搭載后的菌株進(jìn)行復壯、分離和篩選,并進(jìn)行固體發(fā)酵,檢測發(fā)酵產(chǎn)物中洛伐他汀產(chǎn)量。
- Methods: Simvastatin was synthesized from lovastatin via several steps involving acetylization,methylation,hydrolytic decomposition and cyclization reactions. 方法:以洛伐他汀為原料,通過(guò)?；?、甲基化、水解、環(huán)合等反應合成了辛伐他汀。
- And rats of L-NNA+lovastatin-treated group were intraperitonealy injected with L-NNA at dose of 20 mg/kg daily for 3 d in the first three day of lovastatin injection. L-NNA+洛伐他汀處理組大鼠在注射洛伐他汀前3天加L-NNA(20mg/kg)腹腔注射，每天1次，連續3天。
- Furberg CD,Adama AP,Applegate WB,et al.Effect of lovastatin on early carotid atherosclerosis and cardiovascular events (ACAPS)[J].Circulation,1994,90(4):1679. 陸宗良;寇文容;徐義樞;等.;樂(lè )瓦停治療原發(fā)性和繼發(fā)性高脂血癥的臨床觀(guān)察[J]
- This study was designed to investigate the effects of lovastatin on proliferation and gap junctional intercellular communication (GJIC) of MCF 7 human breast cancer cells. 本文探討洛伐他汀對人乳腺癌細胞MCF-7增殖功能以及間隙連接細胞通訊(gapjunctionalintercellularcommunication,GJIC)的影響。
- Objective To study the efficacy and adverse effects of lovastatin combined with metronidazole in treatment of hyperlipidemia, and to explore its possible mechanisms. 摘要目的觀(guān)察小劑量甲硝唑合洛伐他汀調治高脂血癥的療效與副作用，并探討其可能的機理。
- Good separations of polynuclear aromatic compounds, alkylbenzenes, basic aromatic compounds, halobenzenes as well as lovastatin and simvastatin were achieved. 實(shí)驗證明這種交聯(lián)聚合包覆固定相對有機流動(dòng)相和堿具有高穩定性。
- Objective To study the efficacy and adverse effects of lovastatin combined with metronidazole in treatment of hyperlipidemia,and to explore its possible mechanisms. 目的觀(guān)察小劑量甲硝唑合洛伐他汀調治高脂血癥的療效與副作用,并探討其可能的機理。
