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- Ablation of junctin is associated with aberrant Ca homeostasis, which leads to fatal arrhythmias. 去除連接素可導致鈣穩態(tài)異常，進(jìn)一步可引起致命性心律失常。
- Ablation of junctin was associated with enhanced cardiac function in io, and junctin-deficient cardiomyocytes exhibited increased contractile and Ca-cycling parameters. 敲除連接素可增強在體心臟功能，此外，連接素缺陷的心肌細胞可以出現收縮力和鈣循環(huán)參數提高。
- Thus, normal intracellular Ca cycling relies on maintenance of junctin leels and an intricate balance among the components in the sarcoplasmic reticulum quaternary Ca-signaling complex. 因此，正常細胞內鈣循環(huán)依賴(lài)于連接素水平和肌漿網(wǎng)四聯(lián)體鈣信號復合體各組成部分間復雜平衡的維持。
- ligatin 連接素
- junctin 接蛋白,接頭蛋白,銜接蛋白
