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- PRODUCTION OF L DOPA BY IMMOBILIZED PSEUDOMONAS SP. 固定化假單胞菌產(chǎn)L-多巴
- Objective: To observe the effect of chronic levodopa (L dopa) administration on striatal prodynorphin mRNA expression in a rat model of Parkinson disease (PD), and probe into the pathogenesis of L dopa induced dyskinesias (LID). 目的 :觀(guān)察左旋多巴 (L dopa)治療對帕金森病 (PD )大鼠紋狀體強啡肽原表達的影響 ,探討L dopa誘發(fā)異動(dòng)癥 (LID)的機制。
- L dopa induced dyskinesia may disappear or be improved after PVP. 蒼白球腹后部切開(kāi)術(shù)使異動(dòng)癥得到了根本的緩解或消除，從而允許左旋多巴發(fā)揮最大的功效而無(wú)嚴重的副作用。
- AIM The purpose is to synthesize 6 fluoro L DOPA (FDOPA). 目的 :合成 6 氟 L多巴 (FDOPA)。
- After L dopa therapy,the level changes were enhanced ?(P<0.05)?. L-多巴治療后 ;NO、NOS、SOD、GSH-Px進(jìn)一步降低 ;LPO進(jìn)一步增高 (P <0 .;0 5 )。
- Objective To study the neurotoxicity of L dopa and its neuroprotective method. 目的 研究左旋多巴 (L- dopa)的神經(jīng)毒性及其神經(jīng)保護方法。
- METHODS: The models of hypoprolactinemia were established with L dopa in rats. 方法 :采用左旋多巴 (L Dopa)誘導建立哺乳大鼠乳汁分泌低下模型 ;
- The practical technique was provided for the radiochemical synthesis and entiomeric purity of 6 [ 18 F ]fluoro L DOPA. 為 6 [1 8F] L 多巴的放射化學(xué)合成及其對映純度的測定提供了可靠的技術(shù)
- Objective To introduce L dopa test into the preparation of the surgical intervention of PD. 目的 介紹左旋多巴試驗在PD外科治療中的應用價(jià)值。
- Objective To observe the change of antioxidant system in Parkinson disease(PD) and the influence of L dopa. 目的 觀(guān)察帕金森病 (PD)血抗氧化系統變化及 L-多巴的影響。
- METHODS: Tyrosinase activity was estimated by measuring the oxidation rate of L DOPA. 方法 :酪氨酸酶多巴速率氧化法體外測定藥物干預前后酪氨酸酶活性 ,求出酪氨酸酶抑制率。
- After in taking 350mg of L dopa,timed test and non timed test were done every 30 minutes. 先停藥 12小時(shí)以上 ,然后 ,一次性口服左旋多巴 35 0mg ,每隔 30分鐘對病人的狀態(tài)評價(jià)一次 ,共計檢查 30 0分鐘 ;
- Mothods L dopa tests were conducted in 33 cases with PD,after UPDRS rating and Webster rating. 方法 對 33例PD病人 ,在進(jìn)行UPDRS評分和Webster評分后 ,作一次單劑量左旋多巴試驗。
- Large scale production of 6 FDOPA and automatic synthesis of 6 [ 18 F ]fluoro L DOPA with excellent chemical and entiomeric purity are available. 可大量合成 6 FDOPA ,使自動(dòng)合成 6 [1 8F] L 多巴成為可能。
- AIM To study the synthesis and determination for enantiomeric purity of 6 fluoro L 3,4 dihydroxyphenylalanine (6 fluoro L DOPA, 6 FDOPA). 目的 合成 6 氟 L 多巴 (6 FDOPA) ,并測定其對映純度。
- Isolated blood ring assays were used to study the changes of dopamine receptors in rat aorta vascular smooth muscles after oral L dopa. 采用離體血管環(huán)的方法對長(cháng)期服用非亞型特異性擬多巴胺類(lèi)藥物左旋多巴后大鼠主動(dòng)脈平滑肌中多巴胺受體兩亞型（DA1，DA2）的變化進(jìn)行了觀(guān)察。
- Methods:The standard strains were grown on L dopa and bird seed medium.The fragment of CNLAC1 was analyzed by random amplification of genomic DNA. 方法:取標準的產(chǎn)黑素和白化突變菌株分別培養,研究產(chǎn)黑素表型的變化,并用聚合酶鏈反應進(jìn)行CNLAC1目的基因片段的擴增。
- No statistical difference was observed in the improvement percentages of CBPVP, SBPVP1 and SBPVP2. CBPVP contributed greatly to L dopa induced side effects (part IV). 結果 CBPVP、SBPVP1以及SBPVP2均明顯改善患者的整體病情和典型癥狀 (震顫、僵直和行動(dòng)遲緩 ;P <0 0 0 1) ;它們對“關(guān)”狀態(tài)的改善總是高于對“開(kāi)”狀態(tài)的改善。
- CaNa 2EDTA is only used for early manganism treatment. L dopa is effectively for manganism who has suffered from the rigidity and dystonia. However, the adverse effects can easily occur in long|term treatment of manganism when the two drugs are used. CaNa2 EDTA僅適用于早期輕癥錳中毒的治療 ,L dopa對具有肌肉僵直及肌張力障礙的錳中毒治療有效 ,但這 2種藥易出現副作用。
- Objective To explore the activities and the level of antioxidant system in Parkinson disease (PD) and the effect of L dopa and Vit E on it,and find the indications of oxidative stress in PD. 目的 探討帕金森病 (PD)的抗氧化酶 (SOD)活性和過(guò)氧化脂質(zhì) (L PO)代謝水平的變化和多巴藥物及 Vit E對其的影響 ,找出反映氧化異常的客觀(guān)生化指標。
