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- Abstract: BACKGROUND: Gene promoter methylation is an epigenetic eent leading to gene silencing. 摘要：背景：基因啟動(dòng)子甲基化是一種可引起基因沉默的表觀(guān)遺傳事件。
- Gene silencing is a kind of epigenetic phenomenon discovered in transgenic plants in recent years. 摘要基因沉默是近幾年來(lái)在轉基因植物中發(fā)現的一種后生遺傳現象。
- The mechanisms of gene silencing include copy numbers and configuration of transgene, integration sites in plant and transcription of transgene, etc. 基因沉默的機制是多方面的，包括轉基因的拷貝數和構型、在植物上的整合位點(diǎn)、轉基因的轉錄水平等。
- Gene silencing can be divided into two types: position effect and homology dependent gene silencing (HdGS). 基因沉默大體可以分為兩類(lèi)：位置效應引起的基因沉默和同源依賴(lài)的基因沉默。
- Finally, the researchers showed that DNMT1-stimulated HP1 binding is required for gene silencing. 最后，研究者指出DNMT1激發(fā)性Hp1蛋白的結合作用需要基因沉默。
- Posttranscriptional gene silencing(PTGS) is considered to be one of dominant mechanisms of RNA-mediated resistance. 轉錄后基因沉默現象是植物抵御病毒入侵、保持自身基因組完整性的一種防御機制。
- RNA interference (RNAi) is a postranscriptional gene silencing (PTGS) mechanism induced by double-stranded RNA (dsRNA). 摘要RNA干擾，是1種由雙鏈RNA引發(fā)的轉錄后基因沉默現象。
- This mutant showed an increased sensitivity to DNA damage and release of transcriptional gene silencing (TGS) in heterochromatin. 這個(gè)突變體同時(shí)也顯現了對DNA損傷的高敏感性以及在異染色質(zhì)上轉錄基因沉默(TGS)的釋放。
- Abstract:Objective:To observe the effect of PKB gene silencing on the growth of gastric cancer cell line SGC-7901 in vitro. 目的:探討蛋白激酶B（PKB）基因沉默對人胃癌SGC-7901細胞增殖的作用。
- Posttranscriptional gene silencing (PTGS) in plants is a form of RNA silencing by which target RNA is degraded in a sequence-specific manner. 植物中的轉錄后基因沉默(PTGS)是RNA沉默的一種形式，通過(guò)PTGS能對目標RNA進(jìn)行特異性降解。
- From long period evolution with plants, plant virus obtains the ability to code gene silencing suppressors against this defense system. 基因沉默系統是植物抵抗病毒侵染的防衛體系，在長(cháng)期的協(xié)同進(jìn)化過(guò)程中，由病毒編碼的抑制蛋白可以抵消基因沉默系統的作用。
- TMV CP;different constructs;methylation;post transcriptional gene silencing;watermelon;virus diseases;transformation;resistance. 不同結構形式;甲基化;轉錄后基因沉默;西瓜病毒病;轉基因;抗病性
- SET domain proteins of SUV3-9H family specifically methylate the residue lysine 9 of histone H3, resulting in gene silencing. Su(var)3-9家族的SDP專(zhuān)一甲基化組蛋白3第9位賴(lài)氨酸(H3K9),從而導致基因沉默(gene silencing)。
- Transgenic plants with high and stable expression are ideal to get by plant gene engineering, but gene silencing limits their application. 摘要植物基因工程研究是希望獲得高穩定表達的轉基因植株，而轉基因沉默現象卻限制了轉基因植物的應用前景。
- It degrades mRNA specifically and potently through the mediation of corresponding double-stranded RNA and leads to post-transcriptional gene silencing. 它通過(guò)雙鏈RNA的介導特異性地降解相應序列的mRNA，從而導致轉錄后水平的基因沉默。
- The results suggest that gene silencing may be "an efficient and more specific approach for therapy of liver fibrosis," the report states. 報告指出，得到的結果表明基因沉默可能是“一個(gè)有效的和更具體的治療肝纖維化的方法”。
- These phenomena include gene silencing, DNA methylation, nucleolar dominance, transposable elements activation and genomic imprinting. 表觀(guān)遺傳變異包括基因沉默、DNA甲基化、核仁顯性、休眠轉座子激活和基因組印記等方面。
- RNA interference (RNAi) is a post-transcriptional gene silencing induced by introduction of double-stranded RNA(dsRNA). It is a powerful tool for silencing gene expression. RNA干擾(RNA interference,RNAi)是由雙鏈RNA(double-stranded RNA,dsRNA)引發(fā)的轉錄后基因沉默機制(post-transcriptional gene silencing,PTGS),它是沉默基因表達的一個(gè)十分有效的手段。
- A few hypothesis models have been proposed to elucidate the mechanism of gene silencing, but they could not explain all the phenomena in gene silencing. 對于沉默產(chǎn)生的機理，尤其是轉錄后基因沉默，已經(jīng)提出不少模型，但是都未能較全面地解釋基因沉默中出現的各種實(shí)驗現象。
- Post-transcriptional gene silencing (PTGS) is an antiviral defense system of plants, which has led to a new understanding of the relationship between viruses and plants. 基因沉默的發(fā)現使得人們對植物和病毒的相互關(guān)系有了一個(gè)新的認識。
