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- Method: The expression of DDR and its downstream signaling pathways were detected by IHC, WB, RT-PCR and FQ-PCR. 方法:以瘢痕疙瘩組織和KFb為對象,應用IHC、FQ-PCR,WB、RT-PCR研究DDR在瘢痕疙瘩中的表達;
- Focal adhesion kinase (FAK) is a critical mediator that connects integrin and the downstream signal molecules in integrin-signal transduction pathway, and is the convergence of many signal pathways. 黏著(zhù)斑激酶(focal adhesion kinase，FAK)是整合素信號轉導通路中連接整合素與下游信號分子的媒介，處于細胞內多條信號轉導通路的交匯點(diǎn)，能激活多條信號轉導通路。
- All the NBS-LRR proteins for splice forms may have important function in disease resistance and activate downstream signaling pathways. 這些選擇性剪接蛋白可能在抗病信號轉導中起到重要作用。
- Focal adhesion kinase (FAK) is the intermediator linking integrins to downstream signal proteins, and plays a key role in multiple signal pathways. 粘著(zhù)斑激酶（focal adhesion kinase，FAK）則是整合素信號途徑中連接整合素與下級信號分子的媒介，是胞內多條信號途徑的交匯點(diǎn)。
- Axon Guidance 1: Cues, Receptors, and Downstream Signalling Pathways Dickson, B. J. 軸突引導1:因子,接受器和下游信號傳輸。
- Main task: Study the immune-related signaling pathway. 主要研究任務(wù)：免疫細胞信號傳導通路分子機制的研究。
- Scaffold proteins bring together various other proteins in a signaling pathway and allows for their interaction. They recruit downstream effectors in a pathway and enhance specificity of the signal. 支架蛋白是一種在調節信號傳導起著(zhù)重要作用的蛋白質(zhì)，它通過(guò)輔助蛋白激酶和磷酸酶與他們各自的底物結合而起作用。
- The lipid kinase phosphoinositied 3-OH kinase(PI3K) and its downstream target AKT,that is protein kinase B(PKB),plays important roles in carcinogenesis signal pathway reduced by kinds of PTK receptor. 脂類(lèi)激酶PI3K和它的下游靶點(diǎn)Akt,即蛋白激酶B,在各種酪氨酸激酶受體誘導的致癌信號通路中發(fā)揮了重要的作用。
- The ERK signaling pathway is involved in liver fibrosis in many ways. 近年來(lái)發(fā)現其與肝纖維化的關(guān)系密切,可從多方面影響肝纖維化的形成。
- Signaling pathways downstream of pattern-recognition receptors and their cross talk. 信號通路下游的模式識別受體及其相互干擾作用。
- Increasing evidences suggest that signaling pathways downstream of NBS-LRR and NOD proteins are also very similar. 越來(lái)越多的研究表明，二者下游的信號通路也非常相似。
- JNK signaling pathway may play an important role in the apoptosis of Eca-109 cells following COPADG treatment. JNK信號轉導通路在COPADG誘導Eca-109細胞凋亡過(guò)程中發(fā)揮重要作用;COPADG通過(guò)JNK信號通路誘導Eca-109細胞凋亡.
- LPA exert various biological functions through G protein-coupled receptors and the cellular signaling pathways downstream. LPA通過(guò)其受體及耦聯(lián)的G蛋白調節細胞內信號途徑，介導各種生物學(xué)效應。
- Taxol-induced apoptosis in RLECS was not mediated by the Eas/EasL signaling pathway. Taxol對RLECs的Fas及FasL基因的表達無(wú)明顯影響。
- STATs may convert and transmit downstream signal evoked by interaction between cytokines/ growth factors and their ligands. 轉錄因子STATs能將由細胞因子/生長(cháng)因子及其受體相互作用激發(fā)的下游信號進(jìn)行協(xié)調與轉導，同樣酪氨酸激酶JAKs也在信號轉導途徑中起著(zhù)重要作用，二者調控著(zhù)細胞的增殖與分化。
- White speculated that the insulin-like signaling pathway in the brain might promote age-related brain diseases. 懷特推測大腦胰島素樣信號途徑也許促進(jìn)與年齡相關(guān)的大腦疾病。
- This newly identified signaling pathway opens new therapeutic avenues for the treatment of endothelial dysfunction. 這一最新鑒定的信號通路對治療內皮功能障礙開(kāi)辟了新的治療途徑。
- These maturational changes of DCs involved the MyD88-mediated NF-kappaB signaling pathway. 這些樹(shù)狀突細胞的分化改變與MyD88介導的NF-kappaB信號傳導途徑有關(guān)。
- These genes are critical in the signaling pathway for the brain enzyme calcineurin. 這些基因對信號途徑中腦鈣調磷酸酶很關(guān)鍵。
- These small peptides act as ligands to interact with receptor kinases located on the surface of the cytoplasma membrane, triggering downstream signal transductions. 這些小分子多肽化合物以配基的形式與細胞膜表面的受體激酶相互作用，從而實(shí)現細胞之間的信號交流。
