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- dominant negative regulator 顯性抑制調節物, 顯性負性調節物
- Overexpression of wild-type E6-AP in vivo enhanced the ubiquitination of TH1, whereas a dominant negative E6-AP mutant inhibits its ubiquitination. 過(guò)表達野生型的E6-AP會(huì )增強TH1的泛素化；而過(guò)表達泛素連接酶活性缺失E6-AP突變體則會(huì )抑制TH1的這種泛素化。
- It was found that wtFAK and FAKY576F up-regulated GalT gene expression and its surface activity, while dominant negative mutant FAKY397F down-regulated them. 結果發(fā)現wtFAK和FAKY576F上調GalT基因表達和表面酶活性，而FAK的dominant negatiVe突變體FAKY397F下調Galt基因表達和表面酶活性。
- Negative regulation involves the binding of a repressor to the operator to prevent transcription. 在負向可誘導操縱子中，一個(gè)調節的阻遏蛋白質(zhì)一般會(huì )與操縱基因結合，并阻止操縱子中基因的轉錄。若存在著(zhù)一個(gè)誘導物分子，它會(huì )與阻遏基因結合，并改變它的構造，使它不能與操縱基因結合。這可以使操縱基因的轉錄發(fā)生。
- PTP is a negative regulating factor in the MAPK pathway. MAPK級聯(lián)途徑參與有機體的發(fā)育、細胞增殖、激素調節以及逆境脅迫的信號轉導, PTP在MAPK級聯(lián)途徑中主要起負調控作用。
- Here, we found that overexpression of a dominant negative mutant form of human RPL8 (hRPL8), decreased cell and organ size in multiple Drosophila tissues without affecting cell differentiation. 在本文的第二部分中我們過(guò)量表達突變的人類(lèi)基因RPL8可以在身體各組織中影響細胞大小和器官大小但并不影響細胞分化。
- The locomotion of mtm-5 gene knockout group is obviously faster than control group, this suggests that MTM-5 also plays a negative regulation role in the muscle development. mtm-5基因敲除型線(xiàn)蟲(chóng)的運動(dòng)能力明顯比對照組快，暗示其可能與肌肉系統以及整體的發(fā)育存在著(zhù)某種負調控的聯(lián)系。
- CKI plays a negative regulatory role by inhibiting the activity of cyclin-CDK. 細胞周期調節蛋白在細胞周期中的表達和作用已成為當今研究的熱門(mén)話(huà)題。
- Objective: The p33INGlb was first cloned in 1996. It involved in some biological functions, such as negative regulation of cell proliferation and in the control of cellular aging, anchorage dependence and apoptosis. 目的：p33ING1b是1996年被發(fā)現的，它具有多種生物學(xué)功能，在細胞生長(cháng)的負調控、增殖、衰老、腫瘤的錨著(zhù)依賴(lài)性生長(cháng)、凋亡及細胞周期調控點(diǎn)的調節等方面發(fā)揮作用。
- The expression of p16 and Rb protein were significantly correlated with the Dukes staging,especially with stage B.Conclusionp16 and Rb protein make a negative regulation in the P16/CDK/cyclinD/Rb/E 2F pathway. p16蛋白與Rb蛋白表達與Dukes分期顯著(zhù)相關(guān) ,B期表達較C、D期為高。
- HIR/HIRA,encoded by Hir/Hira(histone regulation) genes,were identified as negative regulators of histone gene expression. H ir/H ira基因產(chǎn)物是組蛋白基因表達的一種負調節因子;其在果蠅發(fā)育過(guò)程中的作用還沒(méi)有得到確認.
- CD152, a ligand expressed on the surface of the activated T cells that inhibits co-stimulatory signals, is associated with negative regulation of T-cell activation in the antigen-presenting process. CD152是表達于活化T細胞表面的共刺激信號抑制配體，與抗原遞呈過(guò)程中T細胞活化的負調控有關(guān)。
- HIR/HIRA, one of the histone chaperones, encoded by Hir/Hira (histone regulation) genes, were initially identified in yeast as negative regulators of histone gene expression. 摘要Hir/Hira基因產(chǎn)物HIR/HIRA為組蛋白的伴侶蛋白，最先作為組蛋白基因表達的一種負調節因子從酵母中被鑒定出來(lái)。
- HIR/HIRA,one of the histone chaperones,encoded by Hir/Hira(histone regulation) genes,were initially identified in yeast as negative regulators of histone gene expression. Hir/Hira基因產(chǎn)物HIR/HIRA為組蛋白的伴侶蛋白,最先作為組蛋白基因表達的一種負調節因子從酵母中被鑒定出來(lái)。
- Keywords HBcAg;dominant negative mutant;green fluorescent protein; 乙肝核心抗原;顯性失活突變體;綠色熒光蛋白;
- Peace was the dominant theme of the conference. 和平是大會(huì )的首要議題。
- The NF1 tumor suppressor encodes a protein product neurofibromin,which functions as a negative regulator of RAS. NF1為腫瘤抑制基因,是RAS的負向調節器。
- The right hand is dominant in most people. 大多數人的右手是優(yōu)勢手。
- Dominant negative human telomerase reverase transcriptase gene 人端粒酶逆轉錄酶顯性負突變體
- The negative regulator is simply a unity-gain inverter withinput resistor, R6, and feedback resistor, R7. 負電源整流部分就是一個(gè)簡(jiǎn)單的單位增益反相器，輸入電阻是R6，反饋電阻是R7。
