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- Aimed to find new pesticide with high activity and low toxicity, nine novel benzoyl ureas containing oxime-ether group were synthesized according to bioisoster principle. 為尋找高效、低毒的新農藥,依據活性基團拼接原理,合成了9個(gè)具有肟醚結構的苯甲酰脲類(lèi)化合物。
- The definition of bioisosterism was introduced, together with the kinds of the isosters.Some applications of bioisosterism in pesticide and medicine research were illustrated through classic examples. 介紹了生物電子等排原理的定義和生物電子等排體的分類(lèi)，通過(guò)大量典型事例說(shuō)明了生物電子等排原理在農藥及醫藥研究中的應用。
- The concept,developed history and applications in agrochemicals discovery of bioisosterism were reviewed, and many examples of its successful applications were described in this paper. 本文簡(jiǎn)要敘述了生物等排的概念、發(fā)展史及其作為有效方法之一在新農藥創(chuàng )制中的應用。文中給出許多運用生物電子等排成功開(kāi)發(fā)的新農藥實(shí)例。
- Keywords drug design;structure modification;bioisosterism; 新藥設計;結構改造;生物電子等排;
- bioisoster 生物(電子)等排物, 生物同電異素
- bioisosterism [醫] 生物等排性
