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- The method of HPLC/MS analysis of aristolochic acid A (Aris A A) in Chinese traditional patent medicine(CTPM) was established. 建立了中成藥中馬兜鈴酸A的高效液相色譜/質(zhì)譜檢測方法.
- RESULTS: Aristolochic acid has nephrotoxicity,alimentary canal toxicity,carcinogenicity,mutagenicity and genotoxicity. 結果:馬兜鈴酸具有腎毒性、消化道毒性、致癌性、致突變性和基因毒性。
- Object: To compare the content of Aristolochic acid of different parts in Asarum heterotropoides Fr. 目的:比較不同產(chǎn)地不同部位遼細辛中馬兜鈴酸的痕量。
- Results The main ADR related to aristolochic acid is nephropathy, urothelial cancer being found on some patients. 結果與馬兜鈴酸有關(guān)的不良反應主要為腎損害,部分病例出現尿道上皮癌。
- Cosyns J P,Dehoux J P,Guiot Y.et al.Chronic aristolochic acid toxicity in rabbits:A model of Chinese herbs nephropathy.Kidney Int,2001,59:2164. 文曉彥;鄭法雷;高瑞通;等.;馬兜鈴酸I誘導人腎小管上皮細胞轉分化的作用
- Objective: To investigate the urinary carcinoma in patients with aristolochic acid nephropathy (AAN), in order to improve the levels of diagnosis. 摘要目的:探討馬兜鈴酸腎病患者伴發(fā)泌尿系腫瘤情況,提高認識和診斷水平。
- To analyse the 44 cases of aristolochic acid nephropathy (AAN) in term of pathogeny, clinical symptoms, laboratory results, and some renal pathology. 摘要從近6年收治的腎小管間質(zhì)性疾病中,篩選出馬兜鈴酸腎病患者44例。
- OBJECTIVE To determine the content of Aristolochic Acid A in different parts of Herba cum Radice Asari and in Xuetie Dingchuan Plaster. 目的測定細辛不同藥用部位及其制劑中馬兜鈴酸A的含量。
- Objective:To investigate the urinary carcinoma in patients with aristolochic acid nephropathy(AAN),in order to improve the levels of diagnosis. 目的:探討馬兜鈴酸腎病患者伴發(fā)泌尿系腫瘤情況,提高認識和診斷水平。
- Method Searching published literatures and website associated with aristolochic acid toxicities both domestic and abroad and analyzing them. 方法通過(guò)檢索國內外公開(kāi)發(fā)表的文獻和各國官方網(wǎng)站,收集與馬兜鈴酸有關(guān)的不良反應病例,分析其安全性。
- Gao YL, Chen YP, Dong HR, et al. Experimental study on renal interstitial fibrosis of chronic aristolochic acid nephropahty in rats. Chin J Nephrol2005;21(1):31-35. 高艷麗;諶貽璞;董鴻瑞;等.;慢性馬兜鈴酸腎病腎間質(zhì)纖維化發(fā)病機制的初步探討
- Result:aristolochic acid was founded in 6 species of Aristolochia,and not in the other species of Asarum,Akebia,Clematis,Sinomenium,Stephania,Vladimiric and Aucklandic geneses. 結果:17種相關(guān)中藥材僅馬兜鈴屬6種可檢測出馬兜鈴酸類(lèi)成分。 細辛屬(Asarum)、木通屬(Akebia)、鐵線(xiàn)蓮屬(Clematis)、風(fēng)龍屬(Sinomenium)、千金藤屬(Stephania)、川木香屬(Vladimiric)及云木香屬(Aucklandic)相關(guān)植物中均未檢出相應成分。
- Based on a great deal of etiological research, scholars in our country alleged it should be named by "Aristolochic Acid Nephropathy"(AAN) rather than CHN. 在大量病因學(xué)研究基礎上,我國學(xué)者提出“中草藥腎病”的命名欠妥,應稱(chēng)之為馬兜鈴酸腎病(Aristolochic Acid Nephropathy,AAN)。
- Objective To compare the contents of aristolochic acid in the fruit and seeds of Asarum heterotropoides Fr.Schmidt var. mandshuricum (Maxim.) Kitag. produced in different places. 摘要目的比較遼細辛果實(shí)中不同部位和不同產(chǎn)地遼細辛果實(shí)與種子中馬兜鈴酸A的含量。
- Results:Renal insufficiency caused by AAN was diagnosed in 1 patient after taking the medicine containing aristolochic acid(AA) for a long time(15 years). 結果:長(cháng)期服用含馬兜鈴酸藥物史,并確診為馬兜鈴酸腎病,腎功能不全并發(fā)血尿的患者,手術(shù)證實(shí)腎盂移行細胞癌。
- Methods The contents of aristolochic acid in the fruit and seeds of Asarum heterotropoides Fr.Schmidt var. mandshuricum (Maxim.) Kitag. from different places were tested by HPLC. 方法采用HPLC法對遼細辛果實(shí)中不同部位和不同產(chǎn)地遼細辛種子進(jìn)行馬兜鈴酸A的含量測定。
- The article induced 9 viewpoints to pathogenesy of nephropathy caused by aristolochic acid and reviewed the clinical stage and curing of aristolochic acid nephropathy. 對藥用植物中馬兜鈴酸導致腎病的發(fā)病機制歸納為國內外學(xué)者的9種觀(guān)點(diǎn),并對馬兜鈴酸腎病的臨床分期和治療方法作了綜述。
- Schmidt ver.Mandshuricum(Maxim.) Kitag contained aristolochic acid A or not by HPLC and MS,and the difference in the reference substance and the sample solution was compared. 方法:采用HPLC與MS分別檢測北細辛中的馬兜鈴酸A,并比較對照品和供試品的檢測限。
- The interaction between aristolochic acid and bovine serum albumin (HSA) under physiological conditions was investigated by fluorescence quenching methods. 采用熒光光譜技術(shù)研究了模擬生理條件下馬兜鈴酸與人血清白蛋白(HSA)的相互作用。
- Objective To observe the B- ultrasonic (B-US) renal changes of chronic aristolochic acid nephropathy (CAAN) patients and to determine its value in disease diagnosis. 摘要 目的 探討慢性馬兜鈴酸腎病(CAAN)患者的腎臟B超特征及其對判斷腎臟病變慢性化程度的意義。