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- Keywords X-linked spondyloepiphyseal dysplasia tarda;SEDL gene;acceptor splice site mutation;cryptic splice site activation; 連鎖遲發(fā)性脊椎骨骺發(fā)育不良;SEDL基因;剪接受體突變;潛在剪接位點(diǎn)激活;
- acceptor splicing site 剪接受體
- In this paper, grouped weight matrix (GWM) method is proposed for splice site recognition. 摘要提出識別剪切位點(diǎn)的分組權重矩陣方法。
- The experimental results show that the HMM identification system acquires higher rate in the splice site identification than popular machine learning techniques. 實(shí)驗結果表明，該識別系統在用于剪接位點(diǎn)的識別中較常用的機器學(xué)習方法獲得了更高的識別率。
- Alternative splicing can divide splice sites into alternative donor sites,constitutive donor sites,alternative acceptor sites and constitutive acceptor sites. 選擇性剪切的出現把剪切位點(diǎn)分為選擇性供體位點(diǎn)、組成性供體位點(diǎn)、選擇性受體位點(diǎn)和組成性受體位點(diǎn)。
- Exon 7 splicing mechanism stems from the loss of TRIM5 intron 6 within the first 3 'splice site of the G / T mutation. 外顯子7剪接丟失機制源于TRIM5第6內含子內3’剪接位點(diǎn)的G/T突變。
- In this study, we built a system to detect splice sites in the genomic DNA and to generate all possible isoforms. 其中，雷射振鏡主要用于控制雷射行進(jìn)方向，以及調整雷射焦距，是影響雷射焦點(diǎn)準確性的重要設備。
- In this thesis, we use both Hidden Markov Model (HMM) and Weight Array Model (WAM) to predict the splice sites. 本文基于隱Markov模型(HMM)和權重陣列模型(WAM)兩種方法來(lái)預測剪接位點(diǎn)。
- By masking the mutation, Kole was able to shift splicing back to the normal splice site and restore production of functional hemoglobin. 柯?tīng)柕墓押塑账峥梢哉谏w突變序列，讓剪接體找回正常剪接位，而制造出功能俱全的血紅素。
- The protein has no hydrophobic transmembrane anchor region at the C-terminus and has 19 exons and 18 introns, and splice sites conform to GT/AG rule. 結構分析無(wú)C末端疏水跨膜結構，含有19個(gè)外顯子和18個(gè)內含子，剪切信號符合GT/AG規則。
- GROUPED WEIGHT MATRIX FOR SPLICE SITE RECOGNITION 識別剪切位點(diǎn)的分組權重矩陣方法
- Considering the specialties of the splice sites, the method to encode the DNA sequences, WAM and the HMM themselves are modified to achieve better results. 在使用這兩種方法時(shí)，針對剪接位點(diǎn)本身的特點(diǎn)，本文對HMM本身和WAM本身都做了一定的改進(jìn)。
- orientation-negative splice site 負向拼接位置
- non-competitive splice site pair 非競爭性剪接位點(diǎn)對
- Antisense oligonucleotides could be delivered into cells to mask either a specific splice site or some other regulatory sequence, thereby shifting the splicing activity to another site. 這種寡核苷酸送入細胞后，可以遮蓋住某個(gè)特定的剪接位或調節序列，而將剪接活動(dòng)轉移到其他位置。
- He can splice together the broken ends of ropes quickly. 他能把斷了的繩子頭快速接起來(lái)。
- The monument was moved bodily to a new site. 紀念碑整個(gè)遷到一個(gè)新場(chǎng)址。
- Is it safe to site the power station here? 在這建造發(fā)電廠(chǎng)安全嗎？
- The group goes on a lecture tour of site in greece. 該旅游團前往希臘著(zhù)名景點(diǎn)進(jìn)行修學(xué)旅游。
- The bill of exchange was signed by the acceptor. 匯票由承兌人簽字。
