Verapamil increased the intracellular drug accumulation, and then obviously reversed the drug resistance to DNR, VCR, MIT, HHT, and VP 16 in K562/D cells, but not in the sensitive cells (K562/S).
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- 異搏定使 K 5 6 2 / D細胞內藥物積聚增加 ,明顯地逆轉了 K5 6 2 / D細胞對 DNR、VCR、MIT、HHT、VP- 16的耐藥性 ,而對敏感細胞 K5 6 2 / S的耐藥性無(wú)影響。