Three batyl alcohol derivates were synthesized from fatty acid divinyl ether with batyl alcohol, and then six mutual prodrugs were obtained by further enzymatic transetherification with nucleoside drug (ddI or acyclovir) in nonaqueous organic solvents.
英
美
- 論文研究了非水介質(zhì)中酶促合成核苷和鯊肝醇的復合藥物的方法; 以脂肪酸二乙烯酯利鯊肝醇獲得三種鯊肝醇的單乙烯酯,進(jìn)一步與去羥肌苷和阿昔洛維兩種核苷類(lèi)藥物反應得到6種含有核苷和鯊肝醇的復合藥物;
