Then,the regioselective ortho lithiation of alkyloxypyridine bromide was further performed to produce the diphenylphosphine alkyloxypyridine bromide derivatives(3a,3b and 6a).

 
  • 以氯代吡啶為原料,經(jīng)烷氧基取代,選擇性單溴代,合成了系列烷氧基溴代吡啶,最后利用鋰化反應的區域選擇性,制備了二苯基膦烷氧基溴代吡啶;
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