The relative potency of supernatant increased by 216% and had stable inheritance,after LC47 was treated with repeated multiple mutation with ultraviolet radiation(UV) and diethyl sulphate(DES).

 
  • 經(jīng)紫外線(xiàn)照射(UV)和硫酸二乙酯(DES)多輪復合誘變,LC47發(fā)酵液相對效價(jià)較未誘變前提高了216%25,且具有良好的傳代穩定性。
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