The molecular weight of each component of modified insulin with LA, DHC, LOA and OA was accurately identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS).
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- 利用基質(zhì)輔助激光解吸電離飛行時(shí)間質(zhì)譜(MALDI-TOF-MS)分別確定了LA、DHC、OA和LOA修飾胰島素粗產(chǎn)物的組分及分子量,每種修飾粗產(chǎn)物實(shí)測的各組分的分子量與對應的修飾物理論值完全吻合。
