The intracellular domain of TrkA provides the docking sites, most of them with tyrosine residues such as Y499, Y547, Y638, Y634, for many adaptor proteins including Shc, Grb2, SH2-B, etc.

 
  • 胞內區含有多個(gè)接頭蛋白的結合位點(diǎn),如Shc、Grb2、SH2-B等,其中Y499、Y547、Y638、Y634等酪氨酸位點(diǎn)對于TrkA受體的激活及信號轉導起關(guān)鍵作用。
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