The epitope inducing neutralizing antibody in high variable region 1 (HVR1) is the reason for escape of host immune surveillance, evolution of chronic infection, and also difficulty of producing wide spectrum vaccine.

 
  • 由于誘導中和抗體的抗原表位恰好位于其包膜抗原E2蛋白的高變區 1(HVR1) ,因而容易逃避機體的免疫監視 ,形成慢性感染 ,同時(shí)造成發(fā)展廣譜預防性疫苗的困難。
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