The enhancement of FosB-positive neurons in the NAc or DG could be inhibited by microinjection of M5 muscarinic receptor AS-ONs into the VTA before the heroin-induced locomotor sensitization was performed.

 
  • 海洛因誘導的行為敏化大鼠中NAc及DG中的FosB免疫反應陽(yáng)性神經(jīng)元的表達增加,而在VTA內注射M5AS-ONs能明顯抑制NAc及DG中FosB陽(yáng)性神經(jīng)元表達的增加;
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