The compound 8 was synthesized by 4-nitrophenyl-hydrazine and 2- oxo-propionic acid ethyl ester by nucleophilic addition, rearrangement by total yield 67.9%, and the cost was decreased.

 
  • 以對硝基苯肼、丙酮酸乙酯為原料,經(jīng)親核加成、環(huán)化(2步總收率67.;9%25)合成了化合物8,降低了生產(chǎn)成本。
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