Recent researches indicate that the deletion mutation of MEF2A can attenuate the transcription activation,result in the dysplasia of blood vessel endothelium and stimulate the pathogenesis of coronary artery diseases.

 
  • 近期研究表明,冠心病易感基因MEF2A的突變會(huì )影響其轉錄產(chǎn)物MEF2A蛋白的空間構象,減弱其在肌細胞信號介導的轉錄激活效能,進(jìn)而導致血管內皮發(fā)育不良、單核細胞浸潤,啟動(dòng)動(dòng)脈粥樣硬化斑塊的形成。
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