PD98059 can adhere to disactivated MEK1 ATP locus to inhibit the effect of Raf, therefore block the phosphysating activation of ERK1/2 by MEK1, PD98059 is an ideal blocking agent for in vitro study on the effect of ERK pathway in cell lines.

 
  • 因此目前有關(guān)ERK抑制劑的研究較多,其中PD98059可特異性阻斷ERK上游分子MEK對ERK1/2的磷酸化活化,是體外研究ERK通路在細胞中作用的理想阻斷劑。
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