Overexpression of wild-type Ras enhanced CpG ODN-induced ERK, JNK and NF-xJB reporter gene activation, On the contrary, RasN17 transfection inhibited CpG ODN-induced ERK1/2 and JNK1/2 phosphorylation and NF-KB reporter gene activation.
英
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- 我們用免疫沉淀實(shí)驗發(fā)現CpG ODN還能誘導Ras與TLRg的結合。 同樣條件下non一CpG既不能活化Ras,也不能誘導Ras/T LRg復合物的形成,提示Ras活化以及Ras與TLRg的結合具有CpG基序特異性。