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- OBJECTIVE To synthesize Tropisetron hydrochloride and optimize the process. 目的合成鹽酸托烷司瓊并改進(jìn)其合成工藝。
- METHODS Tropisetron hydrochloride was synthesized by steps of chlorination, esterification, and hydrochlorination. 方法以3-吲哚甲酸為起始原料,經(jīng)氯代、酯化、成鹽酸反應制得長(cháng)烷司瓊。
- The tropisetron hydrochloride capsules were prepared by different methods with starch as main excipient. 以淀粉為主要填充劑,采用不同工藝制備鹽酸托烷司瓊膠囊。
- The tropisetron hydrochloride content was determined by HPLC, and the percentage of dissolution was evaluated. 用高效液相色譜法測定其含量,小杯法測定膠囊體外溶出度。
- Objective:To investigate efficacy of Tropisetron on nausea and vomiting caused by breast cancer chemotherapy. 目的:觀(guān)察托烷司瓊在預防乳腺癌化療所致惡心嘔吐的臨床療效。
- Conclusion Tropisetron hydrochloride and sodium chloride injection is safe and effective on nausea and vomiting induced by chemotherapy. 結論鹽酸托烷司瓊氯化鈉注射液治療化療藥物所致惡心、吐安全有效。
- Tropisetron Hydrochloride was synthesized from 1H-indol-3-carboxylic acid by chloride acetylation and condensation with Tropic alcohol. 摘要以3-吲哚甲酸為起始原料，經(jīng)氯化亞砜酰氯化、與托品醇縮合合成了托烷司瓊鹽酸鹽。
- RESULTS Chemical structure of Tropisetron hydrochloride was confirmed by element analysis,UV,IR, 1HNMR, ESI-MS and EI etc. 結果所得產(chǎn)物經(jīng)元素分析、紫外光譜、紅外光譜、核磁共振譜及質(zhì)譜等確證了結構。
- Objective: To compare the clinical effect and safety of Tropisetron with Granisetron in the prevention of nausea and vomiting induced by anti-cancer drugs. 摘要目的：觀(guān)察國產(chǎn)鹽酸托烷司瓊膠囊預防化療所致惡心嘔吐的臨床療效和安全性，同時(shí)選用格拉司瓊膠囊作對照組進(jìn)行分析。
- Objective To compare and observe the effects of Tropisetron Mesylate (TM) and Metoclopramide (M) in the prevention of chemotherapy-induced digestive side effects. 摘要目的對比觀(guān)察甲磺酸托烷司瓊與甲氧氯普胺兩組藥物控制化療引起的胃腸道反應的療效及其不良反應。
- Conclusion Preoperatively administered tropisetron before tramadol loading dose can effectively reduce the incidence of PONV via the reduction of plasma motilin. 結論曲馬多負荷量術(shù)前給予托烷司瓊能使血清胃動(dòng)素的水平下降，從而更有效地預防惡心、嘔吐。
- Conclusions Tropisetron Mesylate was a new and safety antiemetic drug, which can prevent digestive side effect effectively, and the control of acute emesis was superior to that of meoclopramide. 結論甲磺酸托烷司瓊是一種新的安全的止吐藥，能有效預防化療所致的胃腸道反應，尤其對急性嘔吐的控制顯著(zhù)優(yōu)于甲氧氯普胺。
- OBJECTIVE: To evaluate the preventive efficacy of highly selective 5-HT3 receptor antagonist tropisetron for postoperative nausea and vomiting(PONV) in patients undergoing neurosurgery craniotomy. 目的:評價(jià)高選擇性5-羥色胺(5-HT3)受體拮抗劑托烷司瓊對神經(jīng)外科術(shù)后患者出現的惡心、嘔吐的預防作用。
- Synthesis of antiemetic Tropisetron hydrochloride 止吐藥鹽酸托烷司瓊的合成
- Keywords Tropisetron;Carcinoma;Chemotherapy;Emesis; 托烷司瓊;癌癥;化學(xué)治療;嘔吐;
- Tropisetron Hydrochloride Tablets 鹽酸托烷司瓊片
- Tropisetron hydrochloride/therapeutic application 鹽酸托烷司瓊／治療應用
- Keywords tropisetron;cisplatin;emesis/prevention and control; 歐必亭;順鉑;惡心嘔吐;預防和控制;
- tropisetron hydrochloride and sodium chloride injection 鹽酸托烷司瓊氯化鈉注射液
- Keywords Tropisetron mesylate;metoclopramide;vomit;safety;cisplatin; 甲磺酸托烷司瓊;胃復安;嘔吐;安全性;順鉑;
