Measuring the AUC over 24 h is probably preferable because of circadian variations in physiologic functions and because of possible variations in dosing intervals and absorption rates during a day.

 
  • 由于生理功能的晝夜變化,由于一天內給藥間隔和吸收速率也可能發(fā)生變化,因此,24小時(shí)測一次AUC可能是最好的。
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