Many researches show that Skp2 can interact with many cell cycle regulating factors including p27, and lead to their ubiquitination and degeneration.

 
  • Skp2是F-box蛋白家族的一員。研究發(fā)現,Skp2可與包括p27在內的多種細胞周期調控因子相互作用,導致它們的泛素化降解。
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