Many oncogene proteins are target of effect of HSP90.HSP90 inhibitors will promote the degradation of HSP90 effect proteins,which plays an important role in signaling of tumor growth,...
英
美
- 很多癌基因蛋白均為HSP90的作用靶點(diǎn),HSP90抑制劑將促使在腫瘤生長(cháng)信號通路中起重要作用的HSP90效應蛋白降解,從而阻斷腫瘤增殖信號通路的多個(gè)靶點(diǎn),有效阻止腫瘤的生長(cháng),體內外實(shí)驗也證實(shí)了HSP90抑制劑的抗腫瘤活性。
