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- Janus tyrosine kinases Janus 酪氨酸激酶
- Roles of receptor tyrosine kinases, integrins, and Shc. 外文期刊 Mechanotransduction in response to shear stress.
- Tyrosine kinases are involved in the pathogenesis of most cancers. 酪氨酸激酶參與了大部分腫瘤的發(fā)病。
- Janus protein tyrosin kinases 1 (JAK1) JAK1
- However, few tyrosine kinases have been shown to have a well-defined pathogenetic role in lymphomas. 然而，，很少有酪氨酸激酶在淋巴瘤的發(fā)病中有比較明確的作用。
- In addition, WBZ_4 also inhibited JNK tyrosine kinases - an effect that is known to further protect the heart. 此外， wbz_4也能抑制活性的酪氨酸激酶-大意是眾所周知的，以進(jìn)一步保護心臟。
- Tyrosine kinases are attractive as targets in the research of therapeutic agents, not only against cancer, hut also against many other diseases. 在包括癌癥和其他許多疾病的治療研究中，酪氨酸激酶都是研究的目標和對象。
- The name is soluble f-m-s-like tyrosine kinase one? 這種蛋白質(zhì)叫做可溶解fms樣酪氨酸激酶一，
- Protein tyrosine kinases play an important role in signal transduction pathways in regulating a number of cellular functions. 蛋白質(zhì)酪氨酸在一系列細胞活動(dòng)的信號轉導途徑中起著(zhù)重要的作用。
- But imatinib is known to cause heart problems in some people because it also switches off tyrosine kinases in the ABL family. 但伊馬替尼是眾所周知的導致心臟問(wèn)題，在一些人，因為它還要開(kāi)關(guān)小康酪氨酸激酶在abl的家庭。
- The epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases have close connection with the initiation, progression and progn osis of various malignancies. 表皮生長(cháng)因子受體(EGFR)家族的受體酪氨酸激酶與多種惡性腫瘤的發(fā)生、發(fā)展及預后等密切相關(guān)。
- Moreover, non-cytotoxic agents such as small molecules targeting receptor tyrosine kinases and intracellular signaling pathways have been used in the clinical field. 替莫唑胺及亞硝基脲類(lèi)藥物耐藥性得到了部分解決以及非細胞毒性藥物如酪氨酸激酶抑制劑及細胞間信號傳導通路抑制劑在臨床中的應用。
- Is PDGF tyrosine kinase inhibitor effective in pancreatic cancer? PDGF受體酪氨酸激酶抑制劑在胰腺癌中是否有作用?
- Sorafenib, a novel, oral multi-kinase inhibitor, targets on serine/threonine and receptor tyrosine kinases of the tumor cells and vasculature; blocks the signal transconduction and inhibits tumor growth. 摘要索拉非尼是首個(gè)口服多激酶抑制藥，靶向作用于腫瘤細胞和腫瘤血管上的絲氨酸和（或）蘇氨酸及受體酪氨酸激酶，阻斷信號傳導，抑制腫瘤生長(cháng)。
- IMPLICATIONS: Sevoflurane exerts a preconditioning effect against ischemic cell death in the rat acute hippocampal slice, depending on both tyrosine kinases and duration of ischemia. 七氟烷對抗大鼠海馬切片的缺血細胞死亡的預處理效果，依靠絡(luò )氨酸激酶和缺血的持續時(shí)間。
- The inhibitor of VEGF receptor tyrosine kinase was introduced in detail. 詳細介紹了VEGF受體酪氨酸激酶抑制劑的研究進(jìn)展。
- Sunitinb is a novel multitargeted receptor tyrosine kinase inhibitor. 蘇尼替尼是一種新型的多靶點(diǎn)酪氨酸激酶抑制劑。
- The ABL gene encodes a tyrosine kinase whose activity is tightly regulated. ABL基因編碼一種活性受到嚴格調控的酪氨酸激酶。
- Members in this pathway include the Janus kinases (JAKs) family containing JAK1, JAK2, JAK3 and TYK2 and the STATs (signal transducer and activator of transcription), which contain STAT1 to STAT6. 然而它所影響范疇包括了細胞增生、細胞命運的決定、組織的發(fā)育以及免疫系統反應。哺乳類(lèi)動(dòng)物中，JAK家族有JAK1, JAK2, JAK3 和TYK2，STAT家族則有STAT1-6。
