It suggests that rhG CSF may enhance the sensitivity of drug resitant AML cells to Ara C in vitro by recruiting blasts into the cell cycle. There for , its use in treating AML Patients of drug resistance with rhG CSF and Ara C was recommended.
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- rhG-CSF可能通過(guò)促進(jìn)耐藥AML細胞進(jìn)入增殖周期,而增強Ara-C對耐藥AML細胞的毒性,從而具有耐藥的逆轉效應,預示著(zhù)rhG-CSF與Ara-C聯(lián)合運用治療耐藥AML的潛在價(jià)值