It is suggested that there are common antigenic determinants and similar structurebetween IL-2 and endogenous opioid peptides (EOP). This implies that the analgesic effect of IL-2 might be mediated by interaction between IL-2 and opioid receptors in CNS.
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- 加之內源性阿片肽與IL-2分子有著(zhù)共同的抗原決定基和結構相似性,提示IL-2可以與阿片受體直接結合產(chǎn)生中樞鎮痛效應。