In sharp contrast, all transforming Abl variants are exclusively cytoplasmic, such as Bcr-Abl, even though which contains same NLS and NES sequence as c-Abl. It is critical in inducing human chronic myelogenous leckemia (CML).
英
美
- 例如BCR-Abl,雖然它具有與c-Abl相同的C端序列和NLS、NES,但它只存在于胞質(zhì)中,而且胞質(zhì)中BCR-Abl的組成型活化是導致人類(lèi)慢性粒細胞白血病(CML)的重要原因。