In order to get more structural information for designing new COX-2 inhibitors, COX-2 inhibitors that had been tested for the activity and selectivity were chosen to build two CoMFA model, using CoMFA (comparative molecular field analysis) method.
英
美
- 為得到更多的設計思路,利用已測定活性和選擇性的三環(huán)系COX-2抑制劑分別建立結構與活性和結構與選擇性?xún)蓚€(gè)CoMFA模型。