In natural situation, HBV S gene mutations may appear in long time HBV infected patients, and these mutants could alter the conformation of major hydrophilic region(MHR), such as ThrHlAsn, Metl33Thr, Glyl45Ala, et al.
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- 自然狀態(tài)下,長(cháng)期乙肝病毒感染的患者可出現HBVS基因變異,這些變異(Thr131Asn,Met133Thr,Gly145Ala等)能夠改變MHR區決定簇構象;