In 1996,Ohta et al. identified a candidate tumor suppressor gene FHIT at 3p14.2 by exon trapping experiment. FHIT is classified into the gene family HIT(histidine triad),and as the first common fragile gene to be found,it is easy to rupture.

 
  • FHIT基因是1996年Ohta等以外顯子捕獲法(exon trapping experiment)在3p14.;2區域定位的一個(gè)基因,屬于組氨酸三聯(lián)體(histidine triad,HIT)基因家族,因易于斷裂,故命名為脆性三聯(lián)組氨酸基因(FHIT),覆蓋FRA3B脆性位點(diǎn)。
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