Hydrogen peroxide(H2O2) can reversible deactivate PTEN by forming a disulfide bond between the active -site of Cys124,Cys71.H2O2 can also control PTEN by Egr-1 in transcriptional level.

 
  • 過(guò)氧化氫(H2O2)通過(guò)在活性位點(diǎn)半胱氨酸殘基Cys124與Cys71之間形成二硫鍵,可逆地氧化滅活PTEN。 H2O2還可通過(guò)Egr-1在轉錄水平調控PTEN。
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