However, the main mechanism of the bacterial resistance to macrolides is the modification of the target, the methylation of N~6 on A2058 by peptidyl transferase coded by gene erm, which makes the target not to bind to macrolides.

 
  • 而細菌對大環(huán)內酯的主要耐藥機制是靶點(diǎn)修飾:耐藥基因erm編碼的甲基轉移酶對A2058上的N~6進(jìn)行甲基化,使這一靶點(diǎn)不能與大環(huán)內酯抗生素結合,從而賦予細菌耐藥性。
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