Heat shock protein47(HSP47) is a 47-kDa stress protein that is a collagen-specific molecular chaperone residing in the endoplasmic reticulum (ER). HSP47 is closely involved in the folding, assembly, modification and transport of procollagen.

 
  • 熱休克蛋白47(HSP47)是一種分子量為47KD的蛋白,在內質(zhì)網(wǎng)中能與多種類(lèi)型膠原和前膠原特異性結合,HSP47作為膠原合成有關(guān)的“分子伴侶”,參與前膠原在內質(zhì)網(wǎng)中的折疊、裝配、修飾和轉運等過(guò)程,對膠原分子合成質(zhì)量控制起重要的作用,能夠防止錯誤構型的前膠原分泌出內質(zhì)網(wǎng)。
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