Glomeralar enlargement due to accumulation of extracellular matrix (ECM) accompanied by renal tubular basement membrane thickening and glomerular capillary ultrafiltration are very early characteristics of pathophysiology of diabetic nephropathy.
英
美
- 病理上DN早期特征性地表現為腎臟肥大、腎小球和腎小管基底膜增厚及腎小球內高灌注、高跨膜壓，隨著(zhù)病程的進(jìn)展，可逐漸發(fā)展為腎小球系膜外基質(zhì)(extra cellular matrix，ECM)進(jìn)行性積聚，同時(shí)伴有腎小管-間質(zhì)纖維化，最終發(fā)展為不可逆性腎組織結構毀損。
