GADD153 is an important protein expressed at low levels in the cytoplasm and its expression increases under endoplasmic reticulum (ER) stress and other stresses, then it translocates to the nucleus.
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- GADD153 (Growth arrest- and DNA Damage-induced Gene 153)是在細胞內質(zhì)網(wǎng)應激等應激狀態(tài)下大量表達并轉位于細胞核并調控細胞凋亡的一種重要蛋白[1] ,而且內質(zhì)網(wǎng)應激目前是帕金森病的病理生理機制研究熱點(diǎn)之一,提示GADD153表達在帕金森病的發(fā)病機制中有著(zhù)重要的作用。