Fluoroalkyl acetic acids were converted to their corresponding carbonyl chlorides, which was then reacted with o-amino benzaldehyde and ammonia gas to give 3-(1-iminofluoroalkyl)-1H-qunolin-2-ones in moderate yields.

 
  • 摘要用2-氟烷基乙酸為初始原料,用氯化亞砜或五氯化磷將其轉化為相應的酰氯,后者在室溫與鄰胺基苯甲醛縮合,通入氨氣回流反應得到3-(1-亞胺基氟烷基)-1H-喹啉-2-酮類(lèi)化合物,產(chǎn)率中等。
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